Effet de l'ondansétron sur la pression intracrânienne et la pression de perfusion cérébrale chez le patient neurochirurgical -The effect of ondansetron on intracranial pressure and cerebral perfusion pressure in neurosurgical patients-.
Détails
ID Serval
serval:BIB_74817B97811D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effet de l'ondansétron sur la pression intracrânienne et la pression de perfusion cérébrale chez le patient neurochirurgical -The effect of ondansetron on intracranial pressure and cerebral perfusion pressure in neurosurgical patients-.
Périodique
Annales Françaises d'anesthèsie et de Rèanimation
ISSN
0750-7658 (Print)
ISSN-L
0750-7658
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
17
Numéro
3
Pages
220-226
Langue
français
Notes
Publication types: Clinical Trial ; Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Résumé
OBJECTIVE: To determine the effect of ondansetron on intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP).
STUDY DESIGN: Prospective, comparative, randomized double-blind study.
PATIENTS: Twenty-six patients undergoing intracranial surgery.
METHOD: Induction was obtained with propofol (1-2.5 mg.kg-1), fentanyl (1.5 micrograms.kg-1) and pancuronium (0.1 mg.kg-1), and maintenance was achieved with propofol and fentanyl. Intermittent positive pressure ventilation was used to ensure mild hypocapnia at 35 +/- 2 mmHg. Positioning of the patient was followed by 15 minutes steady-state. Patient received thereafter either 8 mg ondansetron or a placebo intravenously. The ICP was measured using a lumbar malleable spinal needle. CPP was calculated using the formula CCP = MAP-ICP. All variables were measured every minute for 15 minutes.
RESULTS: The ICP, MAP and CPP did not differ between the two groups. There were no differences in the highest ICP values in patients receiving either ondansetron or placebo (11 +/- 5 versus 9 +/- 5, mean +/- SD), respectively.
CONCLUSION: Intravenous administration of 8 mg ondansetron affects neither cerebral hemodynamics nor ICP.
STUDY DESIGN: Prospective, comparative, randomized double-blind study.
PATIENTS: Twenty-six patients undergoing intracranial surgery.
METHOD: Induction was obtained with propofol (1-2.5 mg.kg-1), fentanyl (1.5 micrograms.kg-1) and pancuronium (0.1 mg.kg-1), and maintenance was achieved with propofol and fentanyl. Intermittent positive pressure ventilation was used to ensure mild hypocapnia at 35 +/- 2 mmHg. Positioning of the patient was followed by 15 minutes steady-state. Patient received thereafter either 8 mg ondansetron or a placebo intravenously. The ICP was measured using a lumbar malleable spinal needle. CPP was calculated using the formula CCP = MAP-ICP. All variables were measured every minute for 15 minutes.
RESULTS: The ICP, MAP and CPP did not differ between the two groups. There were no differences in the highest ICP values in patients receiving either ondansetron or placebo (11 +/- 5 versus 9 +/- 5, mean +/- SD), respectively.
CONCLUSION: Intravenous administration of 8 mg ondansetron affects neither cerebral hemodynamics nor ICP.
Mots-clé
Adolescent, Adult, Aged, Anesthetics, Intravenous/administration & dosage, Antiemetics/administration & dosage, Antiemetics/therapeutic use, Blood Pressure/drug effects, Brain/surgery, Cerebrovascular Circulation/drug effects, Double-Blind Method, Female, Fentanyl/administration & dosage, Gastric Emptying/drug effects, Humans, Injections, Intravenous, Intermittent Positive-Pressure Ventilation, Intracranial Pressure/drug effects, Male, Middle Aged, Ondansetron/administration & dosage, Ondansetron/therapeutic use, Placebos, Propofol/administration & dosage, Prospective Studies
Pubmed
Web of science
Création de la notice
17/01/2008 17:19
Dernière modification de la notice
20/08/2019 15:32
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