Omics Approaches in Sleep-Wake Regulation.

Détails

ID Serval
serval:BIB_7447A4A236C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Omics Approaches in Sleep-Wake Regulation.
Périodique
Handbook of experimental pharmacology
Auteur(s)
O'Callaghan E.K., Green E.W., Franken P., Mongrain V.
ISSN
0171-2004 (Print)
ISSN-L
0171-2004
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
253
Pages
59-81
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Although sleep seems an obvious and simple behaviour, it is extremely complex involving numerous interactions both at the neuronal and the molecular levels. While we have gained detailed insight into the molecules and neuronal networks responsible for the circadian organization of sleep and wakefulness, the molecular underpinnings of the homeostatic aspect of sleep regulation are still unknown and the focus of a considerable research effort. In the last 20 years, the development of techniques allowing the simultaneous measurement of hundreds to thousands of molecular targets (i.e. 'omics' approaches) has enabled the unbiased study of the molecular pathways regulated by and regulating sleep. In this chapter, we will review how the different omics approaches, including transcriptomics, epigenomics, proteomics, and metabolomics, have advanced sleep research. We present relevant data in the framework of the two-process model in which circadian and homeostatic processes interact to regulate sleep. The integration of the different omics levels, known as 'systems genetics', will eventually lead to a better understanding of how information flows from the genome, to molecules, to networks, and finally to sleep both in health and disease.
Mots-clé
Homeostasis, Metabolomics/methods, Neurons, Proteomics, Sleep/physiology, Circadian timing system, Epigenomics, Metabolomics, Sleep homeostasis, Transcriptomics
Pubmed
Création de la notice
31/05/2018 18:57
Dernière modification de la notice
24/09/2019 6:11
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