Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role

Détails

ID Serval
serval:BIB_737B1E752C50
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role
Périodique
Gut
Auteur⸱e⸱s
Quinton J. F., Sendid B., Reumaux D., Duthilleul P., Cortot A., Grandbastien B., Charrier G., Targan S. R., Colombel J. F., Poulain D.
Statut éditorial
Publié
Date de publication
06/1998
Volume
42
Numéro
6
Pages
788-91
Langue
anglais
Résumé
BACKGROUND: Perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) are a well recognised marker for ulcerative colitis. Antibodies to oligomannosidic epitopes of the yeast Saccharomyces cerevisiae (ASCA) are a new marker associated with Crohn’s disease. AIMS: To assess the value of detecting pANCA and/or ASCA for the diagnosis of ulcerative colitis and Crohn’s disease. METHODS: Serum samples were obtained from 100 patients with Crohn’s disease, 101 patients with ulcerative colitis, 27 patients with other miscellaneous diarrhoeal illnesses, and 163 healthy controls. Determination of pANCA and ASCA was performed using the standardised indirect immunofluorescence technique and an ELISA, respectively. RESULTS: The combination of a positive pANCA test and a negative ASCA test yielded a sensitivity, specificity, and positive predictive value of 57%, 97%, and 92.5% respectively for ulcerative colitis. The combination of a positive ASCA test and a negative pANCA test yielded a sensitivity, specificity, and positive predictive value of 49%, 97%, and 96% respectively for Crohn’s disease. Among patients with miscellaneous non-inflammatory bowel disorders, three were ASCA positive and two were pANCA positive. One control was ASCA positive. The presence of ASCA in patients with Crohn’s disease was associated with small bowel involvement. CONCLUSION: ASCA and pANCA are strongly associated with Crohn’s disease and ulcerative colitis, respectively. Combination of both tests could help the diagnosis of inflammatory bowel disease.
Mots-clé
Adult, Antibodies, Antineutrophil Cytoplasmic/*blood, Antibodies, Fungal/*blood, Biomarkers/blood, Colitis, Ulcerative/diagnosis/immunology, Crohn Disease/diagnosis/immunology, Female, Fluorescent Antibody Technique, Indirect, Humans, Inflammatory Bowel Diseases/diagnosis/*immunology, Male, Predictive Value of Tests, Saccharomyces cerevisiae/*immunology, Sensitivity and Specificity
Création de la notice
18/07/2019 13:48
Dernière modification de la notice
21/08/2019 6:33
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