The nasal-associated lymphoid tissue of adult mice acts as an entry site for the mouse mammary tumor retrovirus.

Détails

Ressource 1Télécharger: BIB_7329.P001.pdf (201.25 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_7329
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The nasal-associated lymphoid tissue of adult mice acts as an entry site for the mouse mammary tumor retrovirus.
Périodique
Journal of Experimental Medicine
Auteur⸱e⸱s
Velin D., Fotopoulos G., Luthi F., Kraehenbuhl J.P.
ISSN
0022-1007[print], 0022-1007[linking]
Statut éditorial
Publié
Date de publication
1997
Volume
185
Numéro
10
Pages
1871-1876
Langue
anglais
Résumé
Mouse mammary tumor virus (MMTV) is a B type retrovirus transmitted to the suckling offspring through milk. MMTV crosses the intestinal barrier of neonates, initially infects the lymphoid cells of the Peyer's patches, and later spreads to all lymphoid organs and to the mammary gland. Adult mice can be infected systemically, but not by oral MMTV administration. In this study, we show that nasal administration of infected milk induces the infection of adult mice. Nasal MMTV infection shared the main features of systemic and neonatal intestinal MMTV infections: deletion of the superantigen (SAg)-reactive T cell subset from the peripheral T cell population, presence of viral DNA in lymphoid cells, and transmission of MMTV from mother to offspring. Viral DNA was restricted to the lungs and nasal-associated lymphoid tissue (NALT) 6 d after nasal infection. Furthermore, SAg-induced T cell proliferation was only detected in NALT. These results demonstrate that MMTV crosses the intact epithelium of the upper respiratory tract of adult mice and infects the lymphoid follicles associated with these structures.
Mots-clé
Animals, Animals, Newborn, DNA, Viral/analysis, Female, Infectious Disease Transmission, Vertical, Lymphocyte Activation, Lymphoid Tissue/virology, Mammary Tumor Virus, Mouse/isolation &amp, purification, Mammary Tumor Virus, Mouse/pathogenicity, Mice, Mice, Inbred BALB C, Milk/virology, Nasal Mucosa/immunology, Nasal Mucosa/virology, Polymerase Chain Reaction, Retroviridae Infections/immunology, Superantigens/immunology, T-Lymphocyte Subsets/immunology, Tumor Virus Infections/immunology, Tumor Virus Infections/transmission
Pubmed
Web of science
Création de la notice
19/11/2007 12:45
Dernière modification de la notice
20/08/2019 14:31
Données d'usage