Biological markers of alcohol consumption in alcoholised drivers: Comparison of capillary electrophoresis (CZE CDT) and a direct immunoassay (N Latex CDT) with the traditional method of anion-exchange chromatography-immunoturbidimetry (%CDT TIA).
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Version: de l'auteur⸱e
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serval:BIB_72E09462D03D
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Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
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Publications
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Titre
Biological markers of alcohol consumption in alcoholised drivers: Comparison of capillary electrophoresis (CZE CDT) and a direct immunoassay (N Latex CDT) with the traditional method of anion-exchange chromatography-immunoturbidimetry (%CDT TIA).
Titre de la conférence
Tri-Annual Meeting of the International Council on Alcohol, Drugs and Traffic Safety
Adresse
Oslo, Norway, August 22-26, 2010
Statut éditorial
Publié
Date de publication
2010
Langue
anglais
Résumé
Objectives: The aim of this study was to compare specificity and sensitivity of different biological markers that
can be used in a forensic field to identify potentially dangerous drivers because of their alcohol
habits.
Methods: We studied 280 Swiss drivers after driving while under the alcohol influence. 33 were excluded for
not having CDT N results, 247 were included (218 men (88%) and 29 women (12%). Mean age was
42,4 (SD:12, min: 20 max: 76). The evaluation of the alcohol consumption concerned the month
before the CDT test and was considered as such after the interview: Heavy drinkers (>3 drinks per
day): 60 (32.7%), < 3 drinks per day and moderate: 127 (51.4%) 114 (46.5%), abstinent: 60 (24.3%)
51 (21%). Alcohol intake was monitored by structured interviews, self-reported drinking habits and
the C-Audit questionnaire as well as information provided by their family and general practitioner.
Consumption was quantified in terms of standard drinks, which contain approximately 10 grams of
pure alcohol (Ref. WHO).
Results: comparison between moderate (less or equal to 3 drinks per day) and excessive drinkers (more than
3 drinks)
Marker ROC area 95% CI cut-off sensitivity specificity
CDT TIA 0.852 0.786-0917 2.6* 0.93
LR+1.43
0.35
LR-0.192
CDT N latex 0.875 0.821-0.930 2.5* 0.66
LR+ 6.93
0.90
LR- 0.369
Asialo+disialo-tf 0.881 0.826-0.936 1.2* 0.78
LR+4.07
0.80
LR-0.268
1.7° 0.66
LR+8.9
0.93
LR-0.360
GGT 0.659 0.580-0.737 85* 0.37
LR+2.14
0.83
LR-0.764
* cut-off point suggested by the manufacturer
° cut-off point suggested by our laboratory
Conclusion: With the cut-off point established by the manufacturer, CDT TIA performed poorly in term of
specificity. N latex CDT and CZE CDT were better, especially if a 1.7 cut-off is used with CZE
can be used in a forensic field to identify potentially dangerous drivers because of their alcohol
habits.
Methods: We studied 280 Swiss drivers after driving while under the alcohol influence. 33 were excluded for
not having CDT N results, 247 were included (218 men (88%) and 29 women (12%). Mean age was
42,4 (SD:12, min: 20 max: 76). The evaluation of the alcohol consumption concerned the month
before the CDT test and was considered as such after the interview: Heavy drinkers (>3 drinks per
day): 60 (32.7%), < 3 drinks per day and moderate: 127 (51.4%) 114 (46.5%), abstinent: 60 (24.3%)
51 (21%). Alcohol intake was monitored by structured interviews, self-reported drinking habits and
the C-Audit questionnaire as well as information provided by their family and general practitioner.
Consumption was quantified in terms of standard drinks, which contain approximately 10 grams of
pure alcohol (Ref. WHO).
Results: comparison between moderate (less or equal to 3 drinks per day) and excessive drinkers (more than
3 drinks)
Marker ROC area 95% CI cut-off sensitivity specificity
CDT TIA 0.852 0.786-0917 2.6* 0.93
LR+1.43
0.35
LR-0.192
CDT N latex 0.875 0.821-0.930 2.5* 0.66
LR+ 6.93
0.90
LR- 0.369
Asialo+disialo-tf 0.881 0.826-0.936 1.2* 0.78
LR+4.07
0.80
LR-0.268
1.7° 0.66
LR+8.9
0.93
LR-0.360
GGT 0.659 0.580-0.737 85* 0.37
LR+2.14
0.83
LR-0.764
* cut-off point suggested by the manufacturer
° cut-off point suggested by our laboratory
Conclusion: With the cut-off point established by the manufacturer, CDT TIA performed poorly in term of
specificity. N latex CDT and CZE CDT were better, especially if a 1.7 cut-off is used with CZE
Création de la notice
24/02/2011 13:18
Dernière modification de la notice
20/08/2019 15:31
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