Genes mirror geography within Europe.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_72893E0C11ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genes mirror geography within Europe.
Périodique
Nature
Auteur(s)
Novembre J., Johnson T., Bryc K., Kutalik Z., Boyko A.R., Auton A., Indap A., King K.S., Bergmann S., Nelson M.R., Stephens M., Bustamante C.D.
ISSN
1476-4687
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
456
Numéro
7218
Pages
98-101
Langue
anglais
Résumé
Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.
Mots-clé
Emigration and Immigration, Europe/ethnology, Genetic Variation/genetics, Genetics, Population, Genome, Human/genetics, Genome-Wide Association Study, Genotype, Geography, Humans, Phylogeny, Polymorphism, Single Nucleotide, Principal Component Analysis, Quantitative Trait, Heritable, Sample Size, Colaus Study
Pubmed
Web of science
Création de la notice
15/06/2009 8:01
Dernière modification de la notice
20/08/2019 14:30
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