Expression of neutral endopeptidase, endothelin-1, and nuclear factor kappa B in prostate cancer: interrelations and associations with prostate-specific antigen recurrence after radical prostatectomy.

Détails

Ressource 1Télécharger: BIB_726988797C4D.P001.pdf (3477.34 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_726988797C4D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Expression of neutral endopeptidase, endothelin-1, and nuclear factor kappa B in prostate cancer: interrelations and associations with prostate-specific antigen recurrence after radical prostatectomy.
Périodique
Prostate Cancer
Auteur(s)
Vlachostergios P.J., Karasavvidou F., Kakkas G., Moutzouris G., Patrikidou A., Voutsadakis I.A., Daliani D.D., Zintzaras E., Melekos M.D., Papandreou C.N.
ISSN
2090-312X (Electronic)
ISSN-L
2090-312X
Statut éditorial
Publié
Date de publication
2012
Volume
2012
Numéro
452795
Pages
1-8
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP (P < 0.001), cytoplasmic ET-1 (P = 0.002), and cytoplasmic NFκB (P < 0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 (P < 0.001) and NFκB (P < 0.001). ET-1 was also correlated with NFκB (P < 0.001). NEP expression (P = 0.017), pT stage (P = 0.013), and SMs (P = 0.036) were independent predictors of time to PSA recurrence. Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.
Pubmed
Open Access
Oui
Création de la notice
17/01/2013 13:53
Dernière modification de la notice
20/08/2019 14:30
Données d'usage