Clinical and Laboratory Biomarkers as Predictors of Severity in Pediatric Inflammatory Multisystem Syndrome-temporally Associated With SARS-CoV-2: Data From a Prospective Nationwide Surveillance Study in Switzerland.

Détails

ID Serval
serval:BIB_724CA5621090
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical and Laboratory Biomarkers as Predictors of Severity in Pediatric Inflammatory Multisystem Syndrome-temporally Associated With SARS-CoV-2: Data From a Prospective Nationwide Surveillance Study in Switzerland.
Périodique
The Pediatric infectious disease journal
Auteur⸱e⸱s
Wurm J., Uka A., Buettcher M., Kottanattu L., Schöbi N., Trück J., Villiger R., Ritz N., Zimmermann P.
Collaborateur⸱rice⸱s
Swiss Paediatric Surveillance Unit
ISSN
1532-0987 (Electronic)
ISSN-L
0891-3668
Statut éditorial
Publié
Date de publication
01/07/2024
Peer-reviewed
Oui
Volume
43
Numéro
7
Pages
675-681
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Résumé
PIMS-TS (pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2) is a rare but serious condition in children following SARS-CoV-2 infection, characterized by a range of clinical symptoms with varying severity. Understanding risk factors for severe PIMS-TS is crucial for appropriate and timely intervention.
To identify factors associated with increased PIMS-TS severity in children.
In this nationwide prospective observational study, epidemiological and clinical data was collected from children <18 years of age with suspected or confirmed PIMS-TS from all 29 pediatric hospitals in Switzerland. Children were categorized into 3 groups according to admission to intensive care unit (ICU): non-ICU, ICU-moderate and ICU-severe, defined as requirement of invasive ventilation and/or inotropic support.
A total of 204 children were included; 99 (49%) were categorized as non-ICU, 50 (25%) as ICU-moderate and 55 (27%) as ICU-severe. In ICU-severe cases, respiratory and neurological symptoms were more frequent compared with non-ICU cases: 72% versus 47%, P < 0.001 and 66% versus 41%, P = 0.001, respectively. Compared with the non-ICU group, children in the ICU-severe group had lower lymphocyte counts, higher neutrophil-lymphocyte ratios, lower platelet counts, as well as higher C-reactive protein, N-terminal pro-B-type natriuretic peptide, troponin T and creatinine levels at admission. Lymphopenia and elevated troponin T levels at admission were associated with an increased risk of being in the ICU-severe group.
The severity of PIMS-TS may be predicted using clinical symptoms and laboratory biomarkers, which help clinicians in decision-making and management of patients.
Mots-clé
Humans, COVID-19/blood, COVID-19/epidemiology, COVID-19/diagnosis, COVID-19/complications, Switzerland/epidemiology, Systemic Inflammatory Response Syndrome/diagnosis, Systemic Inflammatory Response Syndrome/blood, Systemic Inflammatory Response Syndrome/epidemiology, Child, Prospective Studies, Male, Female, Child, Preschool, Biomarkers/blood, Severity of Illness Index, Infant, Adolescent, SARS-CoV-2, Risk Factors
Pubmed
Web of science
Création de la notice
22/03/2024 12:56
Dernière modification de la notice
13/07/2024 7:09
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