Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study.

Détails

ID Serval
serval:BIB_71C4D07716AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study.
Périodique
Journal of the American Society of Nephrology : Jasn
Auteur⸱e⸱s
Ponte B., Pruijm M., Ackermann D., Vuistiner P., Guessous I., Ehret G., Alwan H., Youhanna S., Paccaud F., Mohaupt M., Péchère-Bertschi A., Vogt B., Burnier M., Martin P.Y., Devuyst O., Bochud M.
ISSN
1533-3450 (Electronic)
ISSN-L
1046-6673
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
26
Numéro
6
Pages
1415-1425
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth in polycystic kidney disease. Whether AVP also affects kidney structure in the general population is unknown. We analyzed the association of copeptin, an established surrogate for AVP, with parameters of renal function and morphology in a multicentric population-based cohort. Participants from families of European ancestry were randomly selected in three Swiss cities. We used linear multilevel regression analysis to explore the association of copeptin with renal function parameters as well as kidney length and the presence of simple renal cysts assessed by ultrasound examination. Copeptin levels were log-transformed. The 529 women and 481 men had median copeptin levels of 3.0 and 5.2 pmol/L, respectively (P<0.001). In multivariable analyses, the copeptin level was associated inversely with eGFR (β=-2.1; 95% confidence interval [95% CI], -3.3 to -0.8; P=0.002) and kidney length (β=-1.2; 95% CI, -1.9 to -0.4; P=0.003) but positively with 24-hour urinary albumin excretion (β=0.11; 95% CI, 0.01 to 0.20; P=0.03) and urine osmolality (β=0.08; 95% CI, 0.05 to 0.10; P<0.001). A positive association was found between the copeptin level and the presence of renal cysts (odds ratio, 1.6; 95% CI, 1.1 to 2.4; P=0.02). These results suggest that AVP has a pleiotropic role in renal function and may favor the development of simple renal cysts.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/10/2014 14:37
Dernière modification de la notice
20/08/2019 14:30
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