Interaction of p-nitrophenylalanine enkephalins with mu-, delta- and kappa-subtypes of the opiate receptor.

Détails

ID Serval
serval:BIB_71C189524271
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interaction of p-nitrophenylalanine enkephalins with mu-, delta- and kappa-subtypes of the opiate receptor.
Périodique
European Journal of Pharmacology
Auteur⸱e⸱s
Fauchère J.L., Do K.Q., Schwyzer R., Robson L.E., Gillan M.G., Paterson S.J., Kosterlitz H.W.
ISSN
0014-2999 (Print)
ISSN-L
0014-2999
Statut éditorial
Publié
Date de publication
1982
Peer-reviewed
Oui
Volume
77
Numéro
4
Pages
339-342
Langue
anglais
Notes
Publication types: In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Substitution of L-p-nitrophenylalanine for phenylalanine in position 4 of [D-Ala2, KLeu-NH2(5)]enkephalin analogues increased their affinity for mu-, delta- and kappa-binding sites in guinea-pig brain, increased their potency to inhibit electrically evoked contractions of the guinea-pig ileum and mouse vas deferens, and increased their analgesic potency in the mouse tail flick test, Introduction of L-adamantylalanine, but not of L-neopentylglycine, in position 5 resulted in a loss of activity.
Mots-clé
Animals, Binding, Competitive, Brain Chemistry, Endorphins/metabolism, Enkephalins/metabolism, Guinea Pigs, Male, Mice, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Receptors, Opioid/metabolism, Receptors, Opioid, delta, Receptors, Opioid, kappa, Receptors, Opioid, mu, Structure-Activity Relationship
Pubmed
Web of science
Création de la notice
06/03/2014 15:57
Dernière modification de la notice
20/08/2019 14:30
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