The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression.

Détails

ID Serval
serval:BIB_71B6B06E0FA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression.
Périodique
Biomaterials
Auteur(s)
Abdel-Sayed P., Darwiche S.E., Kettenberger U., Pioletti D.P.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Statut éditorial
Publié
Date de publication
02/2014
Peer-reviewed
Oui
Volume
35
Numéro
6
Pages
1890-1897
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Mechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffolds. However, the effects of mechanical stimuli on engineered cartilage may vary substantially between different scaffolds. This advocates for the need to identify an overarching mechanobiological variable. We hypothesize that energy dissipation of scaffolds subjected to dynamic loading may be used as a mechanobiology variable. The energy dissipation would furnish a general criterion to adjust the mechanical stimulation favoring chondrogenesis in scaffold. Epiphyseal chondro-progenitor cells were then subject to unconfined compression 2 h per day during four days in different scaffolds, which differ only by the level of dissipation they generated while keeping the same loading conditions. Scaffolds with higher dissipation levels upregulated the mRNA of chondrogenic markers. In contrast lower dissipation of scaffolds was associated with downregulation of chondrogenic markers. These results showed that energy dissipation could be considered as a mechanobiology variable in cartilage. This study also indicated that scaffolds with energy dissipation level close to the one of cartilage favors chondrogenic expression when dynamical loading is present.
Mots-clé
Cartilage/chemistry, Cells, Cultured, Chondrogenesis/physiology, Humans, Polymers/chemistry, Tissue Engineering/methods, Tissue Scaffolds/chemistry, Cartilage, Chondrogenic expression, Dissipation, Dynamic compression, Mechanobiology, Scaffold
Pubmed
Web of science
Création de la notice
10/08/2020 13:08
Dernière modification de la notice
06/09/2020 5:26
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