Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999)
Détails
ID Serval
serval:BIB_71AF6A3B782C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999)
Périodique
J Pediatr Gastroenterol Nutr
Statut éditorial
Publié
Date de publication
07/2005
Volume
41
Numéro
1
Pages
49-55
Langue
anglais
Résumé
OBJECTIVE: To assess the incidence and location at diagnosis of inflammatory bowel disease in children and adolescents in northern France between 1988 and 1999. METHODS: A 12-year prospective population-based study was conducted by gastroenterologists and pediatric gastroenterologists of northern France (1,312,141 children <17 years of age). RESULTS: From 1988 to 1999, 509 cases of childhood inflammatory bowel disease were recorded (7.2% of all inflammatory bowel disease cases in Northern France): 367 Crohn disease, 122 ulcerative colitis and 20 indeterminate colitis. The mean standardized incidence was 3.1/10(5) for inflammatory bowel disease as a whole (2.3 for Crohn disease, 0.8 for ulcerative colitis and 0.12 for indeterminate colitis). Crohn disease location at diagnosis was: small bowel and colon (71%), colon only (10%) and small bowel only (19%). Location of initial ulcerative colitis was: proctitis (11%), left colitis (57%) and pancolitis (32%). Although ulcerative colitis incidence remained stable (0.8), Crohn disease incidence increased from 2.1 in 1988 to 1990 to 2.6 in 1997 to 1999 (P = 0.2). CONCLUSIONS: The incidence of Crohn disease in the children of northern France showed an increasing trend (20%; not significant) during the 12-year period while the incidence of ulcerative colitis remained stable. In the entire population(children and adults)the incidence of Crohn disease increased significantly (+23%; P < 0.001), while the incidence of ulcerative colitis decreased (-17%; P < 0.0001).
Mots-clé
*Population Surveillance, Adolescent, Child, Child, Preschool, Colitis, Ulcerative/epidemiology/pathology, Colon/*pathology, Crohn Disease/epidemiology/pathology, Female, France/epidemiology, Humans, Incidence, Infant, Infant, Newborn, Inflammatory Bowel Diseases/*epidemiology/*pathology, Intestine, Small/*pathology, Longitudinal Studies, Male, Odds Ratio, Prospective Studies
Création de la notice
18/07/2019 13:48
Dernière modification de la notice
21/08/2019 6:33