Comparison of single doses of amoxicillin or of amoxicillin-gentamicin for the prevention of endocarditis caused by Streptococcus faecalis and by viridans streptococci.

Détails

Ressource 1Télécharger: serval:BIB_7177AD00A03B.P001 (660.47 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_7177AD00A03B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparison of single doses of amoxicillin or of amoxicillin-gentamicin for the prevention of endocarditis caused by Streptococcus faecalis and by viridans streptococci.
Périodique
Journal of Infectious Diseases
Auteur(s)
Francioli P., Moreillon P., Glauser M.P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
1985
Volume
152
Numéro
1
Pages
83-89
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Recent recommendations for the prophylaxis of endocarditis in humans have advocated single doses or short courses of antibiotic combinations (beta-lactam plus aminoglycoside) for susceptible patients in whom enterococcal bacteremia might develop or for patients at especially high risk of developing endocarditis (e.g., patients with prosthetic cardiac valves). We tested the prophylactic efficacy (in rats with catheter-induced aortic vegetations) of single doses of amoxicillin plus gentamicin against challenge with various streptococcal strains (two strains of Streptococcus faecalis, one of Streptococcus bovis, and three of viridans streptococci); we then compared this efficacy with that of single doses of amoxicillin alone. Successful prophylaxis against all six strains was achieved with single doses of both amoxicillin alone and amoxicillin plus gentamicin. This protection, however, was limited, for both regimens, to the lowest bacterial-inoculum size producing endocarditis in 90% of control rats and was not extended to higher inocula by using the combination of antibiotics. We concluded that a single dose of amoxicillin alone was protective against enterococcal and nonenterococcal endocarditis in the rat, but that its efficacy was limited and could not be improved by the simultaneous administration of gentamicin.
Mots-clé
Amoxicillin/administration & dosage, Amoxicillin/blood, Animals, Drug Synergism, Drug Therapy, Combination, Endocarditis, Bacterial/microbiology, Endocarditis, Bacterial/prevention & control, Enterococcus faecalis/drug effects, Female, Gentamicins/administration & dosage, Gentamicins/blood, Rats, Rats, Inbred Strains, Streptococcal Infections/microbiology, Streptococcal Infections/prevention & control, Streptococcus/drug effects, Streptococcus sanguis/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:57
Dernière modification de la notice
01/10/2019 6:18
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