Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study.

Détails

ID Serval
serval:BIB_716A14FAD44D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study.
Périodique
International journal of obesity
Auteur(s)
Gapstur S.M., Kopp P., Gann P.H., Chiu B.C., Colangelo L.A., Liu K.
ISSN
0307-0565 (Print)
ISSN-L
0307-0565
Statut éditorial
Publié
Date de publication
04/2007
Peer-reviewed
Oui
Volume
31
Numéro
4
Pages
685-691
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
To compare age-associated 8-year changes in total testosterone, calculated bioavailable testosterone and sex hormone binding globulin (SHBG) across five groups of men stratified according to change in body mass index (BMI) (i.e., BMI stable (+/-0.69 kg/m(2)), decreased (-0.7 kg/m(2)), increased minimally (0.7-1.74 kg/m(2)), increased moderately (1.75-3.19 kg/m(2)) and increased most (> or =3.20 kg/m(2))).
Eight-year longitudinal cohort study.
Four hundred and seventy-four black and 695 white men, aged 24-31 years at the time of the first hormone measurement.
Aging-related changes in serum SHBG, total testosterone and bioavailable testosterone.
SHBG significantly increased with age for men whose BMI decreased, and there were progressively smaller increases for men whose BMI was stable, or whose BMI increased minimally or moderately (range 1.1-0.3 nM per year, P< or =0.03, respectively). There was no age relationship with SHBG among men whose BMI increased most. Total testosterone did not change with age for men whose BMI decreased, was stable or increased minimally, but for men whose BMI increased moderately and most there was a graded decrease in total testosterone with age (beta=-0.2 and -0.4 nM per year, respectively, P< or =0.005). However, bioavailable testosterone decreased with age to a similar extent across all groups.
These results suggest that changes in BMI during young adulthood modulate age-related changes in SHBG and total testosterone, but not bioavailable testosterone.
Mots-clé
Adult, African Continental Ancestry Group, Aging/ethnology, Aging/physiology, Biological Availability, Body Mass Index, Body Weight/physiology, European Continental Ancestry Group, Humans, Longitudinal Studies, Male, Sex Hormone-Binding Globulin/analysis, Testosterone/blood, Testosterone/pharmacokinetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/12/2020 14:18
Dernière modification de la notice
31/12/2020 6:26
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