Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_712862D707D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.
Périodique
Neuron
Auteur⸱e⸱s
Sultan S., Li L., Moss J., Petrelli F., Cassé F., Gebara E., Lopatar J., Pfrieger F.W., Bezzi P., Bischofberger J., Toni N.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
88
Numéro
5
Pages
957-972
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
Publication Status: ppublish
Résumé
Adult neurogenesis is regulated by the neurogenic niche, through mechanisms that remain poorly defined. Here, we investigated whether niche-constituting astrocytes influence the maturation of adult-born hippocampal neurons using two independent transgenic approaches to block vesicular release from astrocytes. In these models, adult-born neurons but not mature neurons showed reduced glutamatergic synaptic input and dendritic spine density that was accompanied with lower functional integration and cell survival. By taking advantage of the mosaic expression of transgenes in astrocytes, we found that spine density was reduced exclusively in segments intersecting blocked astrocytes, revealing an extrinsic, local control of spine formation. Defects in NMDA receptor (NMDAR)-mediated synaptic transmission and dendrite maturation were partially restored by exogenous D-serine, whose extracellular level was decreased in transgenic models. Together, these results reveal a critical role for adult astrocytes in local dendritic spine maturation, which is necessary for the NMDAR-dependent functional integration of newborn neurons.
Mots-clé
Animals, Astrocytes/physiology, Astrocytes/ultrastructure, Clostridium botulinum type B/genetics, Clostridium botulinum type B/metabolism, Dendritic Spines/physiology, Dendritic Spines/ultrastructure, Excitatory Amino Acid Transporter 1/metabolism, Excitatory Postsynaptic Potentials/drug effects, Excitatory Postsynaptic Potentials/genetics, Glial Fibrillary Acidic Protein/genetics, Glial Fibrillary Acidic Protein/metabolism, Hippocampus/cytology, Membrane Potentials/drug effects, Membrane Potentials/physiology, Mice, Mice, Transgenic, Neurogenesis/genetics, Neurogenesis/physiology, Neurons/physiology, Neurons/ultrastructure, Phosphopyruvate Hydratase/metabolism, Receptors, N-Methyl-D-Aspartate/genetics, Receptors, N-Methyl-D-Aspartate/metabolism, SNARE Proteins/genetics, SNARE Proteins/metabolism, Serine/pharmacology, Sodium Chloride/pharmacology, Synapses/genetics, Synapses/physiology, Synaptic Transmission/drug effects, Synaptic Transmission/genetics, Tamoxifen/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/12/2015 11:24
Dernière modification de la notice
20/08/2019 14:29
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