11C-methionine PET for the diagnosis and management of recurrent pituitary adenomas.

Détails

ID Serval
serval:BIB_70F0828E4053
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
11C-methionine PET for the diagnosis and management of recurrent pituitary adenomas.
Périodique
European Journal of Nuclear Medicine and Molecular Imaging
Auteur(s)
Tang B.N., Levivier M., Heureux M., Wikler D., Massager N., Devriendt D., David P., Dumarey N., Corvilain B., Goldman S.
ISSN
1619-7070 (Print)
ISSN-L
1619-7070
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
33
Numéro
2
Pages
169-178
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
PURPOSE: The detection of recurrent pituitary adenoma by magnetic resonance imaging (MRI) is rendered uncertain by the tissue remodelling that follows surgery or radiotherapy. We aimed to evaluate the contribution of PET with 11C-methionine (MET-PET) in the detection and management of recurrent pituitary adenoma.
METHODS: Thirty-three patients with pituitary adenoma were evaluated postoperatively by MET-PET, either because of biological evidence of active residual tumour or because of MRI demonstration of non-functional adenoma growth. We studied 24 secreting adenomas and nine non-functional adenomas.
RESULTS: In 30 patients, MET-PET detected abnormally hypermetabolic tissue. In 14 out of these, MRI did not differentiate between residual tumour and scar formation. In nine of these 14 cases, major therapeutic decisions were undertaken (radiosurgery and surgery). In another group of 16 patients, both MET-PET and MRI detected abnormal tissue. In one case, neither MRI nor MET-PET detected adenomatous tissue. Finally, abnormal tissue was detected in two patients on MRI solely. In these two cases, failure of MET-PET to reveal the adenoma was attributable to concomitant inhibitory therapy. The sensitivity of MET-PET and MRI varied as a function of the tumour type: all non-functional adenomas were localised by both modalities, while MET-PET detected all adrenocorticotropic hormone-secreting adenomas whereas MRI depicted only one of these eight lesions. Fifteen out of 17 patients treated by radiosurgery showed clinical improvement after treatment.
CONCLUSION: We suggest that MET-PET is a sensitive technique complementary to MRI for the detection of residual or recurrent pituitary adenomas. It should gain a place in the efficient management of these tumours.
Mots-clé
Adult, Carbon Radioisotopes/diagnostic use, Female, Humans, Magnetic Resonance Imaging/methods, Male, Methionine/diagnostic use, Middle Aged, Neoplasm, Residual/diagnosis, Pituitary Neoplasms/diagnosis, Pituitary Neoplasms/pathology, Positron-Emission Tomography/methods, Recurrence, Sensitivity and Specificity, Treatment Outcome
Pubmed
Web of science
Création de la notice
20/01/2008 17:35
Dernière modification de la notice
20/08/2019 14:29
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