Exploring Brain Inhibition and Facilitation by Transcranial Magnetic Stimulation: Is there a role of repetitive spinal motor neuron discharges (repMND) in the conventional paired-pulsed paradigm of short intra-cortical inhibition (SICI) and intra-cortical facilitation (ICF)?

Détails

Ressource 1Télécharger: Mémoire no 3283 M. Miaz.pdf (1054.07 [Ko])
Etat: Public
Version: Après imprimatur
ID Serval
serval:BIB_70E01D12A20E
Type
Mémoire
Sous-type
(Mémoire de) maîtrise (master)
Collection
Publications
Institution
Titre
Exploring Brain Inhibition and Facilitation by Transcranial Magnetic Stimulation: Is there a role of repetitive spinal motor neuron discharges (repMND) in the conventional paired-pulsed paradigm of short intra-cortical inhibition (SICI) and intra-cortical facilitation (ICF)?
Auteur(s)
MIAZ B.
Directeur(s)
BENNINGER D.
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Acceptée
Date de publication
2016
Langue
anglais
Nombre de pages
28
Résumé
Objective: To study the role of spinal repMND in the paired-pulsed (PP) paradigms of SICI and ICF by combining PP with TMS, TST, QuadS and QuintS techniques and to explore their variability.
Background: Transcranial magnetic stimulation (TMS) leads to repetitive spinal motor neuron discharges (repMNDs). The paired-pulse TMS (PP-TMS) paradigm allows the exploration of the motor cortex physiology. The triple stimulation technique (TST) and an extended TST-technique including a 4th and 5th stimulation, Quadruple (QuadS) and Quintuple (QuintS) stimulation, respectively, allow a more precise exploration of the central motor conduction and of repMND.
Design/Methods: We explored the PP TMS paradigms of short intracortical inhibition (SICI) with an inter-stimulus interval (ISI) of 2ms and intracortical facilitation (ICF) with an ISI of 10ms in the conventional way (TMS), combined with the TST, and with the QuadS and QuintS in a randomized design in 20 healthy volunteers
Results: About half of the subjects have repMND following a single pulse TMS in the QuadS and QuintS condition (60% and 40%, respectively) and generally more in the QuadS than in the QuintS condition. In both the QuadS and the QuintS, there appear more repMND in the PP-TMS paradigm of ICF than with a single pulse TMS and less than latter in SICI. The variability differs considerably between subjects, but combining the PP paradigms with the TST reduced variability of SICI by -27% but not for ICF or SP. There were subjects showing inhibition and facilitation when the opposite was expected.
Conclusions: These results suggest that there is a contribution of repMND in the conditioned responses of PP-TMS. The large variability precludes their utility in clinical practice. This needs to be further explored.

Mots-clé
TMS, TST, PP-paradigms, MEP, repMND, cortico-spinal excitability
Création de la notice
05/09/2017 13:38
Dernière modification de la notice
20/08/2019 14:29
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