Mechanisms of tissue damage by leukocytes.

Détails

ID Serval
serval:BIB_707702A93320
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mechanisms of tissue damage by leukocytes.
Périodique
Current Opinion In Hematology
Auteur⸱e⸱s
Lehr H.A., Arfors K.E.
ISSN
1065-6251 (Print)
ISSN-L
1065-6251
Statut éditorial
Publié
Date de publication
1994
Volume
1
Numéro
1
Pages
92-99
Langue
anglais
Résumé
Leukocyte adhesion and emigration are involved in host defense and phagocytosis and thus serve a beneficial role during the mounting of a well-contained inflammatory response. However, in certain situations, leukocytes may turn against the host and contribute to tissue damage and organ dysfunction. While trying to summarize the current opinion about the mechanisms by which leukocytes contribute to tissue damage, one finds that leukocyte-inflicted tissue damage involves a network of marked complexity, requiring an orchestrated crosstalk between different cell types, mediators, cytotoxic agents, and their respective inhibitors. Now that an abundance of information is available as to where, when, and how leukocytes contribute to tissue damage, one of the key questions remains unsolved: is leukocyte-inflicted tissue damage true damage, or is it rather a crucial step in tissue repair, healing, and scar formation? Future research will have to address this question, thoroughly differentiating between the role of leukocytes in diverse pathophysiological situations, ranging from cigarette smoke-induced pulmonary emphysema and immune-triggered transplant rejection to myocardial and cerebral infarction. Knowledge of how leukocytes damage tissue only shows us the tools; knowledge of why will provide us with the basis for effective therapeutic interventions.
Mots-clé
Animals, Cell Adhesion, Chemotaxis, Leukocyte, Humans, Inflammation/pathology, Leukocytes/immunology, Leukocytes/physiology, Microcirculation, Phagocytosis
Pubmed
Création de la notice
26/11/2011 16:11
Dernière modification de la notice
20/08/2019 15:29
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