Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells.

Détails

ID Serval
serval:BIB_70680F719C09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells.
Périodique
Biochemical Society Transactions
Auteur(s)
Amici A.W., Onikoyi F.O., Bonfanti P.
ISSN
1470-8752 (Electronic)
ISSN-L
0300-5127
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
42
Numéro
3
Pages
637-644
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Recent evidence supports and reinforces the concept that environmental cues may reprogramme somatic cells and change their natural fate. In the present review, we concentrate on environmental reprogramming and fate potency of different epithelial cells. These include stratified epithelia, such as the epidermis, hair follicle, cornea and oesophagus, as well as the thymic epithelium, which stands alone among simple and stratified epithelia, and has been shown recently to contain stem cells. In addition, we briefly discuss the pancreas as an example of plasticity of intrinsic progenitors and even differentiated cells. Of relevance, examples of plasticity and fate change characterize pathologies such as oesophageal metaplasia, whose possible cell origin is still debated, but has important implications as a pre-neoplastic event. Although much work remains to be done in order to unravel the full potential and plasticity of epithelial cells, exploitation of this phenomenon has already entered the clinical arena, and might provide new avenues for future cell therapy of these tissues.
Pubmed
Web of science
Création de la notice
28/06/2014 16:05
Dernière modification de la notice
20/08/2019 15:29
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