Long-term follow-up of corneal collagen cross-linking for keratoconus--the Cretan study.

Détails

ID Serval
serval:BIB_6FFCB29F23AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term follow-up of corneal collagen cross-linking for keratoconus--the Cretan study.
Périodique
Cornea
Auteur⸱e⸱s
Kymionis G.D., Grentzelos M.A., Liakopoulos D.A., Paraskevopoulos T.A., Klados N.E., Tsoulnaras K.I., Kankariya V.P., Pallikaris I.G.
ISSN
1536-4798 (Electronic)
ISSN-L
0277-3740
Statut éditorial
Publié
Date de publication
10/2014
Peer-reviewed
Oui
Volume
33
Numéro
10
Pages
1071-1079
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The aim of this study was to present the long-term results of corneal collagen cross-linking (CXL) in patients with keratoconus.
In this prospective, interventional case series, patients with progressive keratoconus underwent CXL treatment according to the Dresden protocol. Visual, refractive, and topographic outcomes along with endothelial cell density were evaluated preoperatively and at 1, 2, 3, 4, and 5 years postoperatively.
Twenty-one patients (25 eyes) were enrolled. The mean follow-up was 43.7 ± 12.2 (range, 24-60) months. Logarithm of the minimum angle of resolution (logMAR) mean uncorrected visual acuity and the mean best spectacle-corrected visual acuity improved significantly from 0.92 ± 0.54 and 0.29 ± 0.21 preoperatively to 0.63 ± 0.41 (P = 0.010) and 0.18 ± 0.18 (P = 0.011), respectively, at the last follow-up. Mean steep and mean flat keratometry readings reduced significantly from 52.53 ± 6.95 diopters (D) and 48.11 ± 5.98 D preoperatively to 49.10 ± 4.50 D (P < 0.001) and 45.58 ± 3.81 D (P = 0.001), respectively, at the last follow-up. The mean endothelial cell density was 2708 ± 302 cells per square millimeter preoperatively and did not change significantly (P > 0.05) at any postoperative interval (2593 ± 258 cells/mm at the last follow-up; P = 0.149).
CXL seems to be effective and safe in halting progression of keratoconus over a long-term follow-up period up to 5 years postoperatively.
Mots-clé
Adolescent, Adult, Cell Count, Collagen/metabolism, Corneal Stroma/metabolism, Corneal Topography, Cross-Linking Reagents/therapeutic use, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/physiopathology, Male, Photosensitizing Agents/therapeutic use, Prospective Studies, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Ultraviolet Rays, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Création de la notice
30/09/2019 16:16
Dernière modification de la notice
06/10/2019 5:26
Données d'usage