Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009-2017) in a university Greek hospital.

Détails

ID Serval
serval:BIB_6F88BD89F1A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009-2017) in a university Greek hospital.
Périodique
Infection
Auteur(s)
Papadimitriou-Olivgeris M., Spiliopoulou A., Kolonitsiou F., Bartzavali C., Lambropoulou A., Xaplanteri P., Anastassiou E.D., Marangos M., Spiliopoulou I., Christofidou M.
ISSN
1439-0973 (Electronic)
ISSN-L
0300-8126
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
47
Numéro
2
Pages
209-216
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The aim of the present study was to analyze candidaemia's epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period.
All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI.
During the study period, 505 episodes of candidaemia were observed with an overall incidence of 1.5 episodes per 1000 hospital admissions (1.1 episodes in 2009 to 1.9 in 2017: P 0.038, r 0.694). C. albicans was the leading cause (200 cases; 39.6%), followed by C. parapsilosis (185; 36.6%), C. glabrata (56; 11.1%), C. tropicalis (50; 9.9%), C. krusei (8; 0.2%), C. lusitaniae (5; < 0.1%), and C. guilliermondii (1; < 0.1%). Overall resistance to fluconazole, voriconazole, anidulafungin, caspofungin, and micafungin (according to CLSI) were 11.6%, 4.1%, 2.0%, 6.0%, and 0.8%, respectively. The overall consumption of antifungal drugs was stable, with a significant reduction of fluconazole's use in favor of echinocandins.
An increase in the incidence of candidaemia and a predominance of Candida non-albicans due to decreasing use of fluconazole in favor of more potent antifungals, such as echinocandins, are reported in this study.
Mots-clé
Adult, Aged, Aged, 80 and over, Antifungal Agents/therapeutic use, Candida/isolation & purification, Candidemia/epidemiology, Candidemia/microbiology, Drug Resistance, Fungal, Female, Greece/epidemiology, Hospitals, University/statistics & numerical data, Humans, Incidence, Male, Middle Aged, Species Specificity, Antifungal consumption, Candidaemia, Echinocandins, Fluconazole
Pubmed
Web of science
Création de la notice
19/09/2018 10:23
Dernière modification de la notice
20/08/2019 14:28
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