Differential Brain Mechanisms of Selection and Maintenance of Information during Working Memory.

Détails

ID Serval
serval:BIB_6F62D9164BB5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential Brain Mechanisms of Selection and Maintenance of Information during Working Memory.
Périodique
The Journal of neuroscience
Auteur⸱e⸱s
Quentin R., King J.R., Sallard E., Fishman N., Thompson R., Buch E.R., Cohen L.G.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
08/05/2019
Peer-reviewed
Oui
Volume
39
Numéro
19
Pages
3728-3740
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Working memory is our ability to select and temporarily hold information as needed for complex cognitive operations. The temporal dynamics of sustained and transient neural activity supporting the selection and holding of memory content is not known. To address this problem, we recorded magnetoencephalography in healthy participants performing a retro-cue working memory task in which the selection rule and the memory content varied independently. Multivariate decoding and source analyses showed that selecting the memory content relies on prefrontal and parieto-occipital persistent oscillatory neural activity. By contrast, the memory content was reactivated in a distributed occipitotemporal posterior network, preceding the working memory decision and in a different format than during the visual encoding. These results identify a neural signature of content selection and characterize differentiated spatiotemporal constraints for subprocesses of working memory.SIGNIFICANCE STATEMENT Our brain selects and maintains information during short time windows in a way that is essential to reasoning and learning. Recent advances in multivariate analysis of brain activity allowed the characterization of brain regions that stores the memory. We applied multivariate analysis to time-resolved brain signals to characterize the spatiotemporal signature underlying these subprocesses. The selection of information relies on sustained oscillatory activity in a network that includes the ventrolateral prefrontal cortex while memory content is transiently replayed in an occipitotemporal network that differs from encoding. Our results characterized differentiated spatiotemporal activity underlying encoding, selection, and maintenance of information during working memory.
Mots-clé
Adult, Brain/physiology, Brain Mapping/methods, Female, Humans, Magnetoencephalography/methods, Male, Memory, Short-Term/physiology, Nerve Net/physiology, Photic Stimulation/methods, Psychomotor Performance/physiology, Young Adult, MVPA, decoding, magnetoencephalography, selection rule, temporal dynamics, working memory
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/04/2022 10:32
Dernière modification de la notice
12/04/2022 10:32
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