Cellular Metabolism and Induced Pluripotency.

Détails

ID Serval
serval:BIB_6F3A421D8F7F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cellular Metabolism and Induced Pluripotency.
Périodique
Cell
Auteur⸱e⸱s
Wu J., Ocampo A., Belmonte JCI
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
08/09/2016
Peer-reviewed
Oui
Volume
166
Numéro
6
Pages
1371-1385
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
Mots-clé
Animals, Cellular Reprogramming, Humans, Induced Pluripotent Stem Cells/cytology, Induced Pluripotent Stem Cells/metabolism, Metabolic Diseases/metabolism, Metabolic Networks and Pathways, Models, Biological
Pubmed
Web of science
Création de la notice
14/08/2018 9:29
Dernière modification de la notice
20/08/2019 14:28
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