Alteration of glucose metabolism in cultured astrocytes after AQP9-small interference RNA application.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_6F164A0225BC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Alteration of glucose metabolism in cultured astrocytes after AQP9-small interference RNA application.
Périodique
Brain Research
Auteur(s)
Badaut J., Brunet J.F., Guérin C., Regli L., Pellerin L.
ISSN
1872-6240 (Electronic)
ISSN-L
0006-8993
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
1473
Pages
19-24
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Aquaglyceroporin-9 (AQP9) facilitates diffusion of water and energy substrates such as glycerol and monocarboxylates. AQP9 is present in plasma membrane and mitochondria of astrocytes and catecholaminergic neurons, suggesting that it plays a role in the energetic status of these cells. Using specific small interference RNA directed against AQP9 in astrocyte cultures, we showed that glycerol uptake is decreased which is associated with an increase in glucose uptake and oxidative metabolism. Our results not only confirm the presence of AQP9 in astrocytes but also suggest that changes in AQP9 expression alter glial energy metabolism.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/10/2012 18:16
Dernière modification de la notice
20/08/2019 14:28
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