Photodynamic therapy of nonresectable cholangiocarcinoma

Détails

ID Serval
serval:BIB_6F08010AB4EB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Photodynamic therapy of nonresectable cholangiocarcinoma
Périodique
Gastroenterology
Auteur(s)
Ortner  M. A., Liebetruth  J., Schreiber  S., Hanft  M., Wruck  U., Fusco  V., Muller  J. M., Hortnagl  H., Lochs  H.
ISSN
0016-5085 (Print)
Statut éditorial
Publié
Date de publication
03/1998
Volume
114
Numéro
3
Pages
536-42
Notes
Journal Article --- Old month value: Mar
Résumé
BACKGROUND & AIMS: Successful treatment in nonresectable Bismuth type III and IV cholangiocarcinoma is seldom achieved. The aim of this study was to evaluate the effect of photodynamic therapy on cholestasis, quality of life, and survival in these patients. METHODS: Nine patients with advanced nonresectable cholangiocarcinomas Bismuth type III and IV, who showed no sufficient drainage (bilirubin decrease <50%) after endoscopic stent insertion, underwent photodynamic therapy. Two days after intravenous application of a hematoporphyrin derivate, intraluminal photoactivation was performed cholangioscopically. Serum bilirubin, quality of life, and survival time were assessed in two monthly intervals after photodynamic therapy. RESULTS: After photodynamic therapy, bilirubin serum levels declined from 318 +/- 72 to 103 +/- 35 micromol/L (P = 0.0039) with no significant increase during the two monthly follow-ups. Quality of life indices improved dramatically and remained stable (e.g., Karnofsky index from 32.2% +/- 8.13% to 68.9% +/- 6.1%; P = 0.0078). Thirty-day mortality was 0%, and median survival time was 439 days. CONCLUSIONS: This study provides clear evidence that photodynamic therapy is effective in restoring biliary drainage and improving quality of life in patients with nonresectable disseminated cholangiocarcinomas Bismuth type III and IV. Compared with published data, survival time seems to be prolonged.
Mots-clé
Bile Duct Neoplasms/*drug therapy *Bile Ducts, Intrahepatic Bilirubin/blood Cholangiocarcinoma/*drug therapy/psychology Humans Length of Stay *Photochemotherapy/adverse effects Quality of Life Stents Survival Rate
Pubmed
Web of science
Création de la notice
25/01/2008 16:08
Dernière modification de la notice
20/08/2019 14:28
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