Factors influencing the low density lipoprotein profile in type 2 diabetic patients

Détails

ID Serval
serval:BIB_6EF877B60E37
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Factors influencing the low density lipoprotein profile in type 2 diabetic patients
Périodique
Diabetic Medicine
Auteur(s)
James  R. W., Marini  M., Ruiz  J., Pometta  D.
ISSN
0742-3071
Statut éditorial
Publié
Date de publication
01/1995
Volume
12
Numéro
1
Pages
61-5
Notes
95228292
0742-3071
Journal Article --- Old month value: Jan --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7712707
Résumé
The lipoprotein distribution profile was examined in Type 2 (non-insulin-dependent) diabetic patients (n = 52), with particular emphasis on factors influencing low density lipoproteins (LDL). Triglycerides were negatively correlated with LDL-2 (r = 0.34, p < 0.05) and positively correlated with smaller, denser LDL-3 (r = 0.57, p < 0.001). This yielded a highly significant, negative correlation between triglycerides and the LDL-2/LDL-3 mass ratio (r = -0.59, p < 0.001) which is an indication of the presence of smaller LDL particles. Parameters of glycaemic control, in the form of fasting blood sugar and glycated haemoglobin (HbA1c), were also negatively correlated with the LDL-2/LDL-3 mass ratio in univariate analyses; both remained significantly correlated with the mass ratio when corrected for triglycerides. Stepwise multiple regression analysis identified a three-parameter model comprising triglycerides, HbA1c, and high density lipoprotein cholesterol as best defining the variations in the LDL-2/LDL-3 mass ratio (adjusted r2 = 0.52). These observations are consistent with an independent impact of diabetes on the LDL distribution profile and the possibility that the latter may be subjected to multiple pathological influences in diabetic patients.
Mots-clé
Analysis of Variance Diabetes Mellitus, Non-Insulin-Dependent/*blood Female Hemoglobin A, Glycosylated/analysis Human Lipoproteins, HDL Cholesterol/blood Lipoproteins, LDL/*blood Male Middle Age Support, Non-U.S. Gov't Triglycerides/blood
Pubmed
Web of science
Création de la notice
03/03/2008 15:16
Dernière modification de la notice
20/08/2019 14:28
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