To look beyond vasospasm in aneurysmal subarachnoid haemorrhage.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_6EDE0F4179D1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
To look beyond vasospasm in aneurysmal subarachnoid haemorrhage.
Périodique
Biomed Research International
Auteur(s)
Cossu G., Messerer M., Oddo M., Daniel R.T.
ISSN
2314-6141 (Electronic)
Statut éditorial
Publié
Date de publication
2014
Volume
2014
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Delayed cerebral vasospasm has classically been considered the most important and treatable cause of mortality and morbidity in patients with aneurysmal subarachnoid hemorrhage (aSAH). Secondary ischemia (or delayed ischemic neurological deficit, DIND) has been shown to be the leading determinant of poor clinical outcome in patients with aSAH surviving the early phase and cerebral vasospasm has been attributed to being primarily responsible. Recently, various clinical trials aimed at treating vasospasm have produced disappointing results. DIND seems to have a multifactorial etiology and vasospasm may simply represent one contributing factor and not the major determinant. Increasing evidence shows that a series of early secondary cerebral insults may occur following aneurysm rupture (the so-called early brain injury). This further aggravates the initial insult and actually determines the functional outcome. A better understanding of these mechanisms and their prevention in the very early phase is needed to improve the prognosis. The aim of this review is to summarize the existing literature on this topic and so to illustrate how the presence of cerebral vasospasm may not necessarily be a prerequisite for DIND development. The various factors determining DIND that worsen functional outcome and prognosis are then discussed.
Pubmed
Open Access
Oui
Création de la notice
02/12/2014 0:41
Dernière modification de la notice
28/04/2020 6:09
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