Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness.

Détails

ID Serval
serval:BIB_6ED8F75F2871
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness.
Périodique
Biological psychiatry
Auteur⸱e⸱s
Berna C., Leknes S., Holmes E.A., Edwards R.R., Goodwin G.M., Tracey I.
ISSN
1873-2402 (Electronic)
ISSN-L
0006-3223
Statut éditorial
Publié
Date de publication
01/06/2010
Peer-reviewed
Oui
Volume
67
Numéro
11
Pages
1083-1090
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Depressed mood alters the pain experience. Yet, despite its clear clinical relevance, little is known about the cognitive and neural mechanisms underlying this phenomenon. We tested an experimental manipulation to unravel the interaction between depressed mood and pain. We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood.
Using functional magnetic resonance imaging, we compared the effects of sad and neutral cognitive mood inductions on affective pain ratings, pain-specific cognitions, and central pain processing of a tonic noxious heat stimulus in 20 healthy volunteers.
The increase in negative pain-specific cognitions during depressed mood predicted the perceived increase in pain unpleasantness. Following depressed mood induction, brain responses to noxious thermal stimuli were characterized by increased activity in a broad network including prefrontal areas, subgenual anterior cingulate cortex, and hippocampus, as well as significantly less deactivation when compared with pain responses in a neutral mood. The participants who reported the largest increase in pain unpleasantness after the sad mood induction showed greater inferior frontal gyrus and amygdala activation, linking changes in emotion regulation mechanisms with enhancement of pain affect.
Our results inform how depressed mood and chronic pain co-occur clinically and may serve to develop and translate effective interventions using pharmacological or psychological treatment.

Mots-clé
Adult, Affect/physiology, Analysis of Variance, Brain/physiopathology, Brain Mapping, Cognition, Depression/psychology, Emotions/physiology, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net/physiopathology, Neuropsychological Tests, Pain/physiopathology, Pain/psychology, Pain Measurement, Pain Threshold/psychology, Regression (Psychology)
Pubmed
Web of science
Création de la notice
07/02/2018 18:51
Dernière modification de la notice
20/08/2019 15:27
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