Functional structure and composition of the extracellular matrix

Détails

ID Serval
serval:BIB_6ED42C6C1A04
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Functional structure and composition of the extracellular matrix
Périodique
Journal of Pathology
Auteur⸱e⸱s
Bosman  F. T., Stamenkovic  I.
ISSN
0022-3417 (Print)
Statut éditorial
Publié
Date de publication
2003
Volume
200
Numéro
4
Pages
423-428
Notes
PT - Journal Article PT - Review
Résumé
In this brief introductory paper the general structure and the molecular composition of the extracellular matrix are outlined. Ultrastructural morphology of the extracellular matrix is introduced and subsequently the molecular structure of each of the main protein families, which together make up the extracellular matrix, is reviewed. Collagens, laminins, tenascins, and proteoglycans are addressed. An important common feature is the domain structure of these in general very large proteins. Several families have domains in common, which favours extensive interactions. Integrins play an important role in these interactions and also in the communication between cells and the matrix. The extracellular matrix appears to be a very dynamic structure, which has a prominent role in normal development as well as in a variety of disease processes. Matrix metalloproteinases are essential actors in this complex interplay between cells and the extracellular matrix
Mots-clé
Collagen/ultrastructure/Extracellular Matrix/metabolism/Extracellular Matrix Proteins/Humans/Integrins/Laminin/Matrix Metalloproteinases/Microscopy,Electron/Proteoglycans/Tenascin
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 18:35
Dernière modification de la notice
20/08/2019 14:27
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