Follicle-stimulating hormone bioactivity in idiopathic normogonadotropic oligoasthenozoospermia: double-blind trial with gonadotropin-releasing hormone

Détails

ID Serval
serval:BIB_6ED1CE92458B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Follicle-stimulating hormone bioactivity in idiopathic normogonadotropic oligoasthenozoospermia: double-blind trial with gonadotropin-releasing hormone
Périodique
Fertility and Sterility
Auteur(s)
Crottaz  B., Senn  A., Reymond  M. J., Rey  F., Germond  M., Gomez  F.
ISSN
0015-0282
Statut éditorial
Publié
Date de publication
05/1992
Peer-reviewed
Oui
Volume
57
Numéro
5
Pages
1034-43
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
OBJECTIVE: To identify, among patients with idiopathic normogonadotropic oligoasthenozoospermia, those with low bioactive follicle-stimulating hormone (FSH), possibly because of inadequate gonadotropin-releasing hormone (GnRH) pulsatility, whose bioactive FSH and sperm could be improved by GnRH treatment. DESIGN: Randomized, double-blind, placebo-controlled trial with intranasal (IN) GnRH, followed by open GnRH treatment. SETTING: Outpatient endocrinology clinic. PATIENTS: Twenty-eight infertile men with idiopathic normogonadotropic oligoasthenozoospermia. INTERVENTIONS: Gonadotropin-releasing hormone or placebo was self-administered IN every 2 hours. MAIN OUTCOME MEASURES: Serum immunoreactive and bioactive FSH and semen analyses. RESULTS: Ten men showed a low basal FSH bioactive/immunoreactive ratio, which increased in 5 of them under GnRH without parallel sperm modification. Sperm improvements were observed in 10 patients with no parallel evolution of FSH bioactive/immunoreactive ratio. Unpredicted by sperm changes, three pregnancies developed on placebo and 5 on GnRH. CONCLUSIONS: Low bioactive FSH was not the cause of idiopathic normogonadotropic oligoasthenozoospermia in our patients and could not predict response to GnRH. Pulsatile GnRH did not improve sperm beyond random fluctuations.
Mots-clé
Administration, Intranasal Adult Double-Blind Method Female Follicle Stimulating Hormone/*blood Gonadotropin-Releasing Hormone/blood/*therapeutic use Humans Male Oligospermia/*blood/drug therapy Pregnancy Pulsatile Flow Radioimmunoassay Sperm Count/drug effects
Pubmed
Web of science
Création de la notice
11/02/2008 14:11
Dernière modification de la notice
20/08/2019 14:27
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