Inverse association between circulating vitamin D and mortality-dependent on sex and cause of death?

Détails

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Etat: Supprimée
Version: de l'auteur⸱e
ID Serval
serval:BIB_6EC83103DC37
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inverse association between circulating vitamin D and mortality-dependent on sex and cause of death?
Périodique
Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd
Auteur⸱e⸱s
Rohrmann S., Braun J., Bopp M., Faeh D.
Collaborateur⸱rice⸱s
Swiss National Cohort (SNC)
Contributeur⸱rice⸱s
Gutzwiller F., Bopp M., Egger M., Spoerri A., Zwahlen M., Kuenzli N., Paccaud F., Oris M.
ISSN
1590-3729 (Electronic)
ISSN-L
0939-4753
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
23
Numéro
10
Pages
960-966
Langue
anglais
Résumé
BACKGROUND AND AIMS: In various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and all-cause as well as cause-specific mortality.
METHODS AND RESULTS: The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.
CONCLUSION: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.
Mots-clé
25-Hydroxyvitamin D 2/blood, Adult, Aged, Aging, Calcifediol/blood, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/etiology, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Mortality, Neoplasms/epidemiology, Neoplasms/etiology, Proportional Hazards Models, Risk Factors, Sex Characteristics, Switzerland/epidemiology, Vitamin D Deficiency/blood, Vitamin D Deficiency/epidemiology
Pubmed
Web of science
Création de la notice
21/08/2014 14:25
Dernière modification de la notice
20/08/2019 14:27
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