Inverse association between circulating vitamin D and mortality-dependent on sex and cause of death?
Détails
Demande d'une copieTélécharger: BIB_6EC83103DC37.P001.pdf (1016.89 [Ko])
Etat: Supprimée
Version: de l'auteur⸱e
Etat: Supprimée
Version: de l'auteur⸱e
ID Serval
serval:BIB_6EC83103DC37
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inverse association between circulating vitamin D and mortality-dependent on sex and cause of death?
Périodique
Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd
Collaborateur⸱rice⸱s
Swiss National Cohort (SNC)
Contributeur⸱rice⸱s
Gutzwiller F., Bopp M., Egger M., Spoerri A., Zwahlen M., Kuenzli N., Paccaud F., Oris M.
ISSN
1590-3729 (Electronic)
ISSN-L
0939-4753
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
23
Numéro
10
Pages
960-966
Langue
anglais
Résumé
BACKGROUND AND AIMS: In various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and all-cause as well as cause-specific mortality.
METHODS AND RESULTS: The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.
CONCLUSION: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.
METHODS AND RESULTS: The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.
CONCLUSION: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.
Mots-clé
25-Hydroxyvitamin D 2/blood, Adult, Aged, Aging, Calcifediol/blood, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/etiology, Cohort Studies, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Mortality, Neoplasms/epidemiology, Neoplasms/etiology, Proportional Hazards Models, Risk Factors, Sex Characteristics, Switzerland/epidemiology, Vitamin D Deficiency/blood, Vitamin D Deficiency/epidemiology
Pubmed
Web of science
Création de la notice
21/08/2014 14:25
Dernière modification de la notice
20/08/2019 14:27