New insight in the relationship between regional patterns of knee cartilage thickness, osteoarthritis disease severity, and gait mechanics.

Détails

ID Serval
serval:BIB_6EBF1A9143EE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
New insight in the relationship between regional patterns of knee cartilage thickness, osteoarthritis disease severity, and gait mechanics.
Périodique
Journal of Biomechanics
Auteur(s)
Erhart-Hledik J.C., Favre J., Andriacchi T.P.
ISSN
1873-2380 (Electronic)
ISSN-L
0021-9290
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
48
Numéro
14
Pages
3868-3875
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
To test if the relationship between knee kinetics during walking and regional patterns of cartilage thickness is influenced by disease severity we tested the following hypotheses in a cross-sectional study of medial compartment osteoarthritis (OA) subjects: (1) the peak knee flexion (KFM) and adduction moments (KAM) during walking are associated with regional cartilage thickness and medial-to-lateral cartilage thickness ratios, and (2) the associations between knee moments and cartilage thickness data are dependent on disease severity. Seventy individuals with medial compartment knee OA were studied. Gait analysis was used to determine the knee moments and cartilage thickness was measured from magnetic resonance imaging. Multiple linear regression analyses tested for associations between cartilage thickness and knee kinetics. Medial cartilage thickness and medial-to-lateral cartilage thickness ratios were lower in subjects with greater KAM for specific regions of the femoral condyle and tibial plateau with no associations for KFM in patients of all disease severities. When separated by severity, the association between KAM and cartilage thickness was found only in patients with more severe OA, and KFM was significantly associated with cartilage thickness only for the less severe OA subjects for specific tibial plateau regions. The results support the idea that the KAM is larger in patients with more severe disease and the KFM has greater influence early in the disease process, which may lessen as pain increases with disease severity. Each component influences different regions of cartilage. Thus the relative contributions of both KAM and KFM should be considered when evaluating gait mechanics and the influence of any intervention for knee OA.
Mots-clé
Knee Osteoarthritis, MRI, Knee adduction moment, Knee flexion moment, Gait, Cartilage
Pubmed
Web of science
Création de la notice
10/01/2016 15:35
Dernière modification de la notice
20/08/2019 14:27
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