Functional topography: multidimensional scaling and functional connectivity in the brain.
Détails
ID Serval
serval:BIB_6EB993420280
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Functional topography: multidimensional scaling and functional connectivity in the brain.
Périodique
Cerebral Cortex
ISSN
1047-3211 (Print)
ISSN-L
1047-3211
Statut éditorial
Publié
Date de publication
1996
Volume
6
Numéro
2
Pages
156-164
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
In neuroimaging, functional mapping usually implies mapping function into an anatomical space, for example, using statistical parametric mapping to identify activation foci, or the characterization of distributed changes with spatial modes (eigenimages or principal components) (Friston et al., 1993a). This article is about a complementary approach, namely, mapping anatomy into a functional space. We describe a simple variant of multidimensional scaling (principal coordinates analysis; Gower, 1966) that uses functional connectivity as its metric. The scaling transformation maps anatomy into a functional space. The topography, or proximity relationships, in this space embody the functional connectivity among brain regions. The higher the functional connectivity, the closer the regions. Functional connectivity is defined here as the correlation between remote neurophysiological events. The technique represents a descriptive characterization of anatomically distributed changes in the brain that reveals the structure of corticocortical interactions in terms of functional correlations. To illustrate the approach we have analyzed data from normal subjects and schizophrenic patients obtained with PET during the performance of word generation tasks. In particular, we focus on prefrontotemporal integration in normal subjects and show that, in schizophrenia, the left temporal regions and prefrontal cortex evidence abnormal functional connectivity.
Mots-clé
Brain/physiology, Brain Mapping, Humans, Schizophrenia/physiopathology, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/09/2011 19:09
Dernière modification de la notice
20/08/2019 14:27