Long-term effects of ACTH combined with angiotensin II on steroidogenesis and adrenal zona glomerulosa morphology in the rat.

Détails

ID Serval
serval:BIB_6E621ABAC31D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Long-term effects of ACTH combined with angiotensin II on steroidogenesis and adrenal zona glomerulosa morphology in the rat.
Périodique
Acta endocrinologica
Auteur(s)
Riondel A.M., Rebuffat P., Mazzochi G., Nussdorfer G.G., Gaillard R.C., Bockhorn L., Nussberger J., Vallotton M.B., Muller A.F.
ISSN
0001-5598
Statut éditorial
Publié
Date de publication
1987
Peer-reviewed
Oui
Volume
114
Numéro
1
Pages
47-54
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
To test the hypothesis that the trophic action of angiotensin II on the adrenal zona glomerulosa may allow a sustained stimulation of aldosterone by ACTH by preventing the morphological changes of the zona glomerulosa cells into zona fasciculata-like elements we investigated the effects in rats of a 6-day treatment with ACTH (100 micrograms/kg/day) alone or combined with angiotensin II (300 ng/kg/day) on corticosterone and aldosterone production and adrenal morphology. The responsiveness of both steroids to an acute ACTH dose was also studied on the last day of long-term treatment. Morphologic data showed that prolonged ACTH treatment stimulated the growth of zona glomerulosa cells, though it transformed the tubulo-lamellar cristae of mitochondria into a homogeneous population of vesicles. Angiotensin II furthered the trophic effects of ACTH but prevented the mitochondrial transformation. Despite its ability to conserve the well differentiated aspect of the zona glomerulosa cells, the administration of angiotensin II was unable to prevent the fall in the secretion of aldosterone caused by chronic ACTH treatment and its subsequent unresponsiveness to ACTH stimulation.
Mots-clé
Adrenal Glands, Adrenocorticotropic Hormone, Aldosterone, Angiotensin II, Animals, Corticosterone, Male, Mitochondria, Rats, Rats, Inbred Strains, Time Factors
Pubmed
Web of science
Création de la notice
05/03/2008 16:40
Dernière modification de la notice
20/08/2019 14:27
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