Effects of oleic acid-, alpha-naphthylthiourea-, and phorbol myristate acetate-induced microvascular damage on indexes of pulmonary endothelial function in anesthetized dogs

Détails

ID Serval
serval:BIB_6E27DC2F1267
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of oleic acid-, alpha-naphthylthiourea-, and phorbol myristate acetate-induced microvascular damage on indexes of pulmonary endothelial function in anesthetized dogs
Périodique
American Review of Respiratory Disease
Auteur(s)
Gardaz  J. P., Py  P., Suter  P. M., Junod  A. F.
ISSN
0003-0805 (Print)
Statut éditorial
Publié
Date de publication
06/1988
Volume
137
Numéro
6
Pages
1350-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
To study the value of indexes of endothelial cell function in experimentally induced pulmonary microvascular injury, lung damage was produced in anesthetized dogs by intravenous injection of oleic acid (OA; n = 6), alpha-naphthylthiourea (ANTU; n = 5), or phorbol myristate acetate (PMA; n = 6). Angiotensin-converting enzyme (ACE) activity in serum and simultaneous measurements of serotonin (SER) and propranolol (PROP) pulmonary extraction along with several physiologic parameters were determined and compared with those obtained in a control group (n = 5) before and then at 2-h intervals for 8 h after administration of the toxic agent. ACE activity in serum showed a sustained and significant increase in the PMA and OA groups throughout the whole study period, whereas it decreased significantly at 4 h in the ANTU group. SER pulmonary uptake decreased significantly, but slightly, only in the PMA group at 8 h (-5%). At 6 and 8 h respectively, PROP extraction dropped significantly in the PMA (-11 and -13%) and OA (-13 and -19%) groups. This decrease in PROP extraction was likely to result from physiologic changes due to the development of pulmonary edema as suggested by the correlation between the changes in amine uptake and those affecting pulmonary artery pressure and total static respiratory compliance. The lack of effects on SER uptake by the lungs under these experimental conditions indicate that dissociation exists between metabolic dysfunction of pulmonary endothelial cells and fluid leakage.
Mots-clé
Anesthesia Animals Blood Pressure Dogs Endothelium, Vascular/pathology/*physiopathology Lung/metabolism Lung Diseases/blood/chemically induced/*physiopathology Microcirculation Oleic Acid Oleic Acids/*pharmacology Peptidyl-Dipeptidase A/blood Propranolol/pharmacokinetics *Pulmonary Circulation Serotonin/pharmacokinetics *Tetradecanoylphorbol Acetate/pharmacology Thiourea/*analogs & derivatives/pharmacology Vascular Diseases/blood/chemically induced/*physiopathology Vascular Resistance
Pubmed
Web of science
Création de la notice
28/01/2008 11:48
Dernière modification de la notice
20/08/2019 15:27
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