Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions
Détails
ID Serval
serval:BIB_6DF473692FA3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions
Périodique
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
06/1992
Volume
175
Numéro
6
Pages
1789-1792
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun 1
Résumé
The receptors that mediate monocyte adhesion to cytokine-stimulated endothelial monolayers were assessed using a nonstatic (rotating) cell-attachment assay. In this system, leukocyte adhesion molecule-1 (LAM-1) (L-selectin) mediated a major portion (87 +/- 15% at 37 degrees C) of monocyte attachment to activated endothelium. mAb blocking of endothelial leukocyte adhesion molecule-1 (41% inhibition), CD18 (36%), and vascular cell adhesion molecule-1 (25%) function had lesser effects on attachment. These results suggest that LAM-1 may serve an important role in monocyte attachment to endothelium at sites of inflammation.
Mots-clé
Antibodies, Monoclonal Antigens, CD/physiology Antigens, CD18 *Cell Adhesion/drug effects Cell Adhesion Molecules/biosynthesis/immunology/*physiology Cell Line Endothelium, Vascular/drug effects/*physiology Humans L-Selectin Monocytes/drug effects/*physiology Receptors, Leukocyte-Adhesion/physiology Tumor Necrosis Factor-alpha/drug effects Umbilical Veins Vascular Cell Adhesion Molecule-1
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:31
Dernière modification de la notice
20/08/2019 15:27