Skin cancer in survivors of childhood and adolescent cancer.

Détails

ID Serval
serval:BIB_6DC367012796
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Skin cancer in survivors of childhood and adolescent cancer.
Périodique
European Journal of Cancer
Auteur(s)
Levi F., Moeckli R., Randimbison L., Van-Cong Te, Maspoli M., La Vecchia C.
ISSN
0959-8049
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
42
Numéro
5
Pages
656-659
Langue
anglais
Résumé
The incidence of basal cell carcinoma (BCC) has been related to ionizing radiation, particularly for exposure occurring at young age. In this study, we considered the incidence of second skin neoplasms in long-term survivors from childhood cancer. We considered second primary cancers occurring among 776 subjects (436 males, 340 females) with first primary cancer diagnosed before age 20 years, between 1974 and 2001, in the Swiss Cantons of Vaud and Neuchâtel (786,000 inhabitants). Five BCC were observed versus 0.43 expected (standardized incidence ratio: 11.6, 95% confidence interval: 3.7-27.1). No case of cutaneous squamous cell carcinoma, nor of malignant melanoma was observed. The estimated radiation doses at 1mm through the skin ranged between 7 and 27 Sv. These data confirm that BCC are strongly related to ionizing radiation exposure in childhood. All the BCC were located within the radiation field, thus indicating that ionizing radiation is the key aetiological factor, even in the absence of any meaningful interaction with UV.
Mots-clé
Adolescent, Adult, Age of Onset, Carcinoma, Basal Cell/etiology, Carcinoma, Basal Cell/mortality, Female, Humans, Incidence, Male, Neoplasms, Radiation-Induced/etiology, Neoplasms, Radiation-Induced/mortality, Neoplasms, Second Primary/mortality, Radiotherapy/adverse effects, Skin Neoplasms/etiology, Skin Neoplasms/mortality, Survivors, Switzerland/epidemiology
Pubmed
Web of science
Création de la notice
28/04/2008 10:35
Dernière modification de la notice
20/08/2019 14:27
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