Pretherapeutic Functional Imaging Allows Prediction of Head Tremor Arrest After Thalamotomy for Essential Tremor: The Role of Altered Interconnectivity Between Thalamolimbic and Supplementary Motor Circuits.

Détails

ID Serval
serval:BIB_6D77A87AEC70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pretherapeutic Functional Imaging Allows Prediction of Head Tremor Arrest After Thalamotomy for Essential Tremor: The Role of Altered Interconnectivity Between Thalamolimbic and Supplementary Motor Circuits.
Périodique
World neurosurgery
Auteur⸱e⸱s
Tuleasca C., Régis J., Najdenovska E., Witjas T., Girard N., Champoudry J., Faouzi M., Thiran J.P., Cuadra M.B., Levivier M., Van De Ville D.
ISSN
1878-8769 (Electronic)
ISSN-L
1878-8750
Statut éditorial
Publié
Date de publication
04/2018
Peer-reviewed
Oui
Volume
112
Pages
e479-e488
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To correlate pretherapeutic resting-state functional magnetic resonance imaging (rs-fMRI) measures with pretherapeutic head tremor presence and/or further improvement 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for essential tremor (ET).
We prospectively collected head tremor scores (range, 0-3) and rs-fMRI data for a cohort of 17 consecutive ET patients in pretherapeutic and 1 year after SRS-T states. We additionally acquired rs-fMRI data for a healthy control (HC) group (n = 12). Group-level independent component analysis (n = 17 for pretherapeutic rs-fMRI) was applied to decompose neuroimaging data into 20 large-scale brain networks using a standard approach. Through spatial regression, we projected 1 year after SRS-T and HC rs-fMRI time points, on the same 20 brain networks.
Pretherapeutic interconnectivity (IC) strength between the network including bilateral thalamus and limbic system with left supplementary motor area predicted head tremor improvement at 1 year after SRS-T (family-wise corrected P < 0.001, cluster size K <sub>c</sub>  = 146). For the statistically significant cluster, IC strength was strongest in HCs (mean, 4.6; median, 3.8) compared with pre- (mean, 0.1; median, 0.2) or posttherapeutic (mean, -0.2; median, 0.09) states.
Baseline measures of IC between bilateral thalamus and limbic system with left supplementary motor area may predict head tremor arrest after thalamotomy. However, procedures such as SRS-T, for this particular clinical feature, do not align patients to HCs in terms of functional brain connectivity. We postulate that supplementary motor area is modulating head tremor appearance, by abnormal connectivity with the thalamolimbic system.
Mots-clé
Aged, Aged, 80 and over, Essential Tremor/diagnostic imaging, Essential Tremor/surgery, Female, Functional Neuroimaging/methods, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging/methods, Male, Middle Aged, Motor Cortex/diagnostic imaging, Motor Cortex/surgery, Neural Pathways/diagnostic imaging, Neurosurgical Procedures/methods, Prospective Studies, Thalamus/diagnostic imaging, Thalamus/surgery, Treatment Outcome, Essential tremor, Head tremor, Resting state, Stereotactic radiosurgery, Thalamotomy, Ventrointermediate nucleus, fMRI
Pubmed
Web of science
Création de la notice
08/02/2018 17:43
Dernière modification de la notice
20/08/2019 14:27
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