From Pregnancy to Preeclampsia: A Key Role for Estrogens.
Détails
ID Serval
serval:BIB_6D43A4F42AFC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
From Pregnancy to Preeclampsia: A Key Role for Estrogens.
Périodique
Endocrine reviews
ISSN
1945-7189 (Electronic)
ISSN-L
0163-769X
Statut éditorial
Publié
Date de publication
01/04/2017
Peer-reviewed
Oui
Volume
38
Numéro
2
Pages
123-144
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily in the placenta by conversion of androgen precursors originating from maternal and fetal adrenal glands. These processes lead to increased plasma estrogen concentrations compared with levels in nonpregnant women. Aberrant production of estrogens could play a key role in PE symptoms because they are exclusively produced by the placenta and they promote angiogenesis and vasodilation. Previous assessments of estrogen synthesis during PE yielded conflicting results, possibly because of the lack of specificity of the assays. However, with the introduction of reliable analytical protocols using liquid chromatography/mass spectrometry or gas chromatography/mass spectrometry, more recent studies suggest a marked decrease in estradiol levels in PE. The aim of this review is to summarize current knowledge of estrogen synthesis, regulation in the placenta, and biological effects during pregnancy and PE. Moreover, this review highlights the links among the occurrence of PE, estrogen biosynthesis, angiogenic factors, and cardiovascular risk factors. A close link between estrogen dysregulation and PE occurrence might validate estrogen levels as a biomarker but could also reveal a potential approach for prevention or cure of PE.
Mots-clé
Animals, Estrogens/biosynthesis, Female, Humans, Placenta Diseases/metabolism, Placenta Diseases/physiopathology, Pre-Eclampsia/metabolism, Pre-Eclampsia/physiopathology, Pregnancy
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/09/2023 13:24
Dernière modification de la notice
27/09/2023 9:59