Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_6CE9EEBF7E86
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Périodique
Nature communications
Auteur⸱e⸱s
Georgopoulou D., Callari M., Rueda O.M., Shea A., Martin A., Giovannetti A., Qosaj F., Dariush A., Chin S.F., Carnevalli L.S., Provenzano E., Greenwood W., Lerda G., Esmaeilishirazifard E., O'Reilly M., Serra V., Bressan D., Mills G.B., Ali H.R., Cosulich S.S., Hannon G.J., Bruna A., Caldas C.
Collaborateur⸱rice⸱s
IMAXT Consortium
Contributeur⸱rice⸱s
Ali H.R., Al Sa'd M., Alon S., Aparicio S., Battistoni G., Balasubramanian S., Becker R., Bodenmiller B., Boyden E.S., Bressan D., Bruna A., Burger M., Caldas C., Callari M., Cannell I.G., Casbolt H., Chornay N., Cui Y., Dariush A., Dinh K., Emenari A., Eyal-Lubling Y., Fan J., Fatemi A., Fisher E., González-Solares E.A., González-Fernández C., Goodwin D., Greenwood W., Grimaldi F., Hannon G.J., Harris O., Harris S., Jauset C., Joyce J.A., Karagiannis E.D., Kovačević T., Kuett L., Kunes R., Küpcü Y.A., Lai D., Laks E., Lee H., Lee M., Lerda G., Li Y., McPherson A., Millar N., Mulvey C.M., Nugent F., O'Flanagan C.H., Paez-Ribes M., Pearsall I., Qosaj F., Roth A.J., Rueda O.M., Ruiz T., Sawicka K., Sepúlveda L.A., Shah S.P., Shea A., Sinha A., Smith A., Tavaré S., Tietscher S., Vázquez-García I., Vogl S.L., Walton N.A., Wassie A.T., Watson S.S., Weselak J., Wild S.A., Williams E., Windhager J., Whitmarsh T., Xia C., Zheng P., Zhuang X.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
31/03/2021
Peer-reviewed
Oui
Volume
12
Numéro
1
Pages
1998
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes and their oncogenic signalling states in a biobank of patient-derived tumour xenograft (PDTX) models representing the diversity of human breast cancer. The BCMC panel identifies 13 cellular phenotypes (11 human and 2 murine), associated with both breast cancer subtypes and specific genomic features. Pre-treatment cellular phenotypic composition is a determinant of response to anticancer therapies. Single-cell profiling also reveals drug-induced cellular phenotypic dynamics, unravelling previously unnoticed intra-tumour response diversity. The comprehensive view of the landscapes of cellular phenotypic heterogeneity in PDTXs uncovered by the BCMC panel, which is mirrored in primary human tumours, has profound implications for understanding and predicting therapy response and resistance.
Mots-clé
Animals, Benzamides/pharmacology, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Drug Resistance, Neoplasm/drug effects, Drug Resistance, Neoplasm/genetics, Female, Heterografts/drug effects, Heterografts/metabolism, Humans, MCF-7 Cells, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, Morpholines/pharmacology, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Pyrimidines/pharmacology, Treatment Outcome, Xenograft Model Antitumor Assays/methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/04/2021 17:16
Dernière modification de la notice
12/01/2022 7:10
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