Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_6CCA5A0A9918
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.
Périodique
Frontiers in Immunology
Auteur(s)
Kypriotou M., Rivero D., Haller S., Mariotto A., Huber M., Acha-Orbea H., Werner S., Hohl D.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2013
Volume
4
Numéro
246
Pages
1-10
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
Activin A, a member of the TGFβ superfamily, is involved in physiological processes such as cell differentiation, tissue homeostasis, wound healing, reproduction, and in pathological conditions, such as fibrosis, cancer, and asthma. Activin enhances mast cell maturation, as well as regulatory T-cell and Langerhans cell differentiation. In this study we investigated the potential role of activin in epicutaneous sensitization with ovalbumin (OVA), notably with respect to its effect on known Th2-polarization. For this purpose, transgenic mice overexpressing activin in keratinocytes and their wild-type (WT) controls were sensitized epicutaneously with OVA. Skin biopsies were analyzed with regard to histopathological features and mRNA expression of pro-inflammatory and Th1/Th2 cytokines, and Ig levels were measured in the serum. Unexpectedly, activin overexpressing animals were protected from Th2-cytokine expression and induction of OVA-specific IgE levels compared to WT animals. On the other hand, transgenic mice were more susceptible to inflammation compared to WT littermates after tape-stripping and saline (vehicle) or OVA application, as shown by increased pro-inflammatory cytokine mRNA levels and neutrophil accumulation at the site of the treatment. We conclude that activin protects from antigen-induced cutaneous Th2-polarization through modulation of the immune response. These findings highlight the role of activin in cutaneous sensitization, allergy, and in skin homeostasis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/01/2014 14:32
Dernière modification de la notice
20/08/2019 14:26
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