The "Papez circuit" is an important anatomical substrate of memory and emotion. To date, however, no attempt has been done to show the structural basis of this circuit in-vivo, probably due to its convoluted shape and complex nature. In this investigation, we disentangled the anatomical structure of the "Papez Circuit" in humans using high-angular resolution diffusion spectrum imaging tractography. In six subjects, we could consistently map the hippocampus-mamillary body pathway, the pathway connecting the lateral subiculum to the cingulated cortex and the tract connecting the mamillary body to the thalamus, where higher level integration of cognition is performed.