The number of positive nodes accurately predicts recurrence after pancreaticoduodenectomy for nonfunctioning neuroendocrine neoplasms.

Détails

ID Serval
serval:BIB_6C9E6254590B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The number of positive nodes accurately predicts recurrence after pancreaticoduodenectomy for nonfunctioning neuroendocrine neoplasms.
Périodique
European journal of surgical oncology
Auteur(s)
Partelli S., Javed A.A., Andreasi V., He J., Muffatti F., Weiss M.J., Sessa F., La Rosa S., Doglioni C., Zamboni G., Wolfgang C.L., Falconi M.
ISSN
1532-2157 (Electronic)
ISSN-L
0748-7983
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
44
Numéro
6
Pages
778-783
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
The most appropriate nodal staging for pancreatic neuroendocrine neoplasms (PanNENs) is unclear. Aim of the study was to evaluate the effect of the number of positive lymph nodes on prognosis after pancreaticoduodenectomy for PanNENs.
A retrospective analysis of pancreaticoduodenectomies for nonfunctioning PanNENs was performed. PanNENs with nodal metastases (N+) were classified into N1 (1 to 3 positive lymph nodes) and N2 (4 or more positive lymph nodes). Univariate and multivariate analyses of disease-free survival were performed.
157 patients were included. 99 patients (63%) had N0 PanNENs whereas 58 patients (37%) had nodal involvement (N+). Patients with N0 PanNENs had a 3-year disease-free survival rate of 89% compared with 83% and 75% in patients with N1 and N2 PanNENs, respectively (P < 0.0001). Independent predictors of disease-free survival were the presence of necrosis, lymph node ratio and nodal status. Factors positively correlated with the number of positive lymph nodes were the Ki67 value, the T stage and the number of examined lymph nodes. Similar percentage of N0 and N+ PanNENs was demonstrated for a cut-off of 13 examined lymph nodes.
The number of positive lymph nodes is accurate in predicting recurrence for PanNENs. Thirteen examined lymph nodes seems to be the minimum number of lymph nodes to be resected/examined in patients who undergo pancreaticoduodenectomy for PanNENs.
Mots-clé
Abdomen, Aged, Biopsy, Fine-Needle, Disease-Free Survival, Endosonography, Female, Follow-Up Studies, Humans, Liver Neoplasms/diagnosis, Liver Neoplasms/secondary, Lymph Node Excision, Lymph Nodes/pathology, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Staging, Neuroendocrine Tumors/diagnosis, Neuroendocrine Tumors/secondary, Neuroendocrine Tumors/surgery, Pancreatic Neoplasms/mortality, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/surgery, Retrospective Studies, Survival Rate/trends, Switzerland/epidemiology, Tomography, X-Ray Computed, United States/epidemiology, Disease-free survival, Lymph node metastases, Pancreatic neuroendocrine neoplasms, Pancreaticoduodenectomy, Prognosis, Surgery
Pubmed
Web of science
Création de la notice
06/04/2018 17:07
Dernière modification de la notice
20/08/2019 15:26
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