Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy
Détails
ID Serval
serval:BIB_6C7849F27449
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy
Périodique
European Journal of Anaesthesiology
ISSN
0265-0215
Statut éditorial
Publié
Date de publication
02/2001
Peer-reviewed
Oui
Volume
18
Numéro
2
Pages
75-8
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Feb
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Feb
Résumé
BACKGROUND AND OBJECTIVE: This study compares the effect of oral clonidine vs. hydroxyzine on the haemodynamic and catecholamine responses to microlaryngoscopy. METHODS: Thirty-five ASA II-III patients were included in this double-blind randomized trial. The patients received either hydroxyzine 1 mg kg-1 (n = 18) or clonidine 3 micrograms kg-1 (n = 17) for their oral premedication 100 min before an intravenous induction of anaesthesia using propofol (2-3 mg kg-1) and fentanyl (2 micrograms kg-1). Arterial pressure and heart rate were measured before premedication, and throughout the procedure and recovery. Plasma catecholamine levels were determined before premedication, after induction, and 1.5, 30 and 120 min after laryngoscopy. RESULTS: Mean arterial pressure was significantly lower after clonidine, whereas there was no difference in heart rate and plasma catecholamine levels between the two groups. CONCLUSIONS: Clonidine for premedication significantly decreased mean arterial pressure during microlaryngoscopy and the following recovery phase but did not modify the overall haemodynamic response to the suspension microlaryngoscopic nociceptive stimulus.
Mots-clé
*Adrenergic alpha-Agonists
*Anti-Anxiety Agents
Blood Pressure/drug effects
Catecholamines/*blood
*Clonidine
Double-Blind Method
Female
Heart Rate/drug effects
Hemodynamics/*drug effects
Humans
*Hydroxyzine
Male
Middle Aged
*Preanesthetic Medication
Prospective Studies
Pubmed
Web of science
Création de la notice
17/01/2008 17:19
Dernière modification de la notice
20/08/2019 15:26