Osteopontin and bone metabolism in healing cranial defects in rabbits

Détails

ID Serval
serval:BIB_6C65EFE75448
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Osteopontin and bone metabolism in healing cranial defects in rabbits
Périodique
International Journal of Oral and Maxillofacial Surgery
Auteur⸱e⸱s
Gordjestani  M., Dermaut  L., De  R. L., De  W. P., De  L. W., Bosman  F.
ISSN
0901-5027 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
35
Numéro
12
Pages
1127-1132
Notes
PT - Journal Article
Résumé
Non-collagen proteins such as bone sialoprotein and osteopontin (OPN) form 10% of the extracellular bone matrix. In this study, the influence of OPN on bone repair was investigated. Human OPN (Innogenetics) was produced by a recombinant technique and bonded onto the surface of hydroxyapatite (Interpore 200). Thirty rabbits were divided into six equal groups. A circular defect (10mm) was prepared in each parietal bone. In four rabbits of each group the left and right defects were filled with either OPN-coated hydroxyapatite (OPN-HA) or non-coated hydroxyapatite (HA). One sham animal of each group received no implants. The animals were killed after 1, 2, 6, 12, 18 and 30 weeks. The histological sections were scanned and analysed digitally. There were no statistically significant differences in total bone formation between defects filled with OPN-HA and HA. Bone formation at the borders of the healing area was significantly higher in defects filled with OPN-HA than in those filled with HA. Less bone formation was noted in the OPN-HA and HA groups at the centre of the healing area than at the borders of the healing area and the dural area. Although some animals in the sham group showed a high level of bone formation in the dural area, this was not significantly different to that in the dural area of the other groups. There was no sign of infection or tissue rejection of the graft
Mots-clé
Animals/Bone Substitutes/pharmacology/therapeutic use/Durapatite/Humans/Osteopontin/Photography/Rabbits/Skull/injuries/metabolism/surgery/Wound Healing/drug effects
Pubmed
Web of science
Création de la notice
29/01/2008 19:34
Dernière modification de la notice
20/08/2019 15:26
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