Acute coronary syndrome in patients younger than 30 years--aetiologies, baseline characteristics and long-term clinical outcome.

Détails

Ressource 1Télécharger: smw.2013.13816.pdf (489.15 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_6BEC09649FD5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acute coronary syndrome in patients younger than 30 years--aetiologies, baseline characteristics and long-term clinical outcome.
Périodique
Swiss medical weekly
Auteur⸱e⸱s
Puricel S., Lehner C., Oberhänsli M., Rutz T., Togni M., Stadelmann M., Moschovitis A., Meier B., Wenaweser P., Windecker S., Stauffer J.C., Cook S.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
29/07/2013
Peer-reviewed
Oui
Volume
143
Pages
w13816
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Coronary atherosclerosis begins early in life, but acute coronary syndromes in adults aged <30 years are exceptional. We aimed to investigate the rate of occurrence, clinical and angiographic characteristics, and long-term clinical outcome of acute coronary syndrome (ACS) in young patients who were referred to two Swiss hospitals.
From 1994 to 2010, data on all patients with ACS aged <30 years were retrospectively retrieved from our database and the patients were contacted by phone or physician's visit. Baseline, lesion and procedural characteristics, and clinical outcome were compared between patients in whom an underlying atypical aetiology was found (non-ATS group; ATS: atherosclerosis) and patients in whom no such aetiology was detected (ATS group). The clinical endpoint was freedom from any major adverse cardiac event (MACE) during follow-up.
A total of 27 young patients with ACS aged <30 years were admitted during the study period. They accounted for 0.05% of all coronary angiograms performed. Mean patient age was 26.8 ± 3.5 years and 22 patients (81%) were men. Current smoking (81%) and dyslipidaemia (59%) were the most frequent risk factors. Typical chest pain (n = 23; 85%) and ST-segment elevation myocardial infarction (STEMI; n = 18 [67%]) were most often found. The ATS group consisted of 17 patients (63%) and the non-ATS group of 10 patients (37%). Hereditary thrombophilia was the most frequently encountered atypical aetiology (n = 4; 15%). At 5 years, mortality and MACE rate were 7% and 19%, respectively.
ACS in young patients is an uncommon condition with a variety of possible aetiologies and distinct risk factors. In-hospital and 5-year clinical outcome is satisfactory.

Mots-clé
Acute Coronary Syndrome/etiology, Acute Coronary Syndrome/mortality, Acute Coronary Syndrome/therapy, Adult, Cocaine-Related Disorders/complications, Coronary Angiography, Coronary Artery Disease/complications, Dyslipidemias/epidemiology, Endocarditis/complications, Familial Mediterranean Fever/complications, Female, Follow-Up Studies, Humans, Male, Myocardial Infarction/etiology, Myocardial Infarction/mortality, Myocardial Infarction/therapy, Percutaneous Coronary Intervention, Retrospective Studies, Risk Factors, Smoking/epidemiology, Thrombophilia/complications, Treatment Outcome, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/08/2017 11:04
Dernière modification de la notice
20/08/2019 14:26
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