Low molecular weight heparin Novo (LHN-1) does not cross the placenta during the second trimester of pregnancy

Détails

ID Serval
serval:BIB_6BD08F2444BC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Low molecular weight heparin Novo (LHN-1) does not cross the placenta during the second trimester of pregnancy
Périodique
Thrombosis and Haemostasis
Auteur(s)
Omri  A., Delaloye  J. F., Andersen  H., Bachmann  F.
ISSN
0340-6245 (Print)
Statut éditorial
Publié
Date de publication
02/1989
Volume
61
Numéro
1
Pages
55-6
Notes
Journal Article --- Old month value: Feb 28
Résumé
Unfractionated heparin (UF-H) has been the drug of choice for the treatment of thromboembolic disorders during pregnancy. Low molecular weight heparin (LMW-H) preparations may present some advantages over UF-H. They have longer half-lives and a better bioavailability after subcutaneous (s. c.) injection and may cause less bleeding. It has not yet been established whether LMW-H Novo (LHN-1) crosses the placenta. 17 women admitted for abortion during the second trimester of pregnancy (induced by application of prostaglandine PGE2 gel at a concentration of 0.25 mg/ml into the cervix) were given s. c. 35 anti-Xa units per kg of body weight of LHN-1 (Novo). 10 patients not receiving LHN-1 and their fetuses served as a control group. 7 women in whom the time interval between injection of LHN-1 and expulsion of the fetus was less than 3 h or more than 7 h were excluded from further study. In one fetus blood collection failed. Anti-Xa and anti-IIa levels increased approximately ten-fold in women receiving LHN-1 [anti-Xa units/ml from 0.02 +/- 0.01 (mean +/- SD) to 0.17 +/- 0.01, p less than 0.001; anti-Ha units/ml from less than 0.01 +/- 0.01 to 0.07 +/- 0.03], but remained below the detection limit in their fetuses as well as in the women and fetuses of the control group. We conclude that LHN-1 at these doses does not cross the placenta during the second trimester of pregnancy to suggest that LHN-1 may be a safe alternative to heparin in the management of the thromboembolic complications during pregnancy.
Mots-clé
Abortion, Induced Adolescent Adult Factor Xa Female Fetal Blood/analysis Heparin, Low-Molecular-Weight/*pharmacokinetics Humans *Maternal-Fetal Exchange Pregnancy Pregnancy Trimester, Second Prothrombin/antagonists & inhibitors Serine Proteinase Inhibitors
Pubmed
Web of science
Création de la notice
25/01/2008 16:42
Dernière modification de la notice
20/08/2019 15:26
Données d'usage