Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine.

Détails

Ressource 1Télécharger: 1-s2.0-S221112471501284X-main.pdf (2278.04 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_6B2A857A3672
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine.
Périodique
Cell Reports
Auteur⸱e⸱s
Glangetas C., Fois G.R., Jalabert M., Lecca S., Valentinova K., Meye F.J., Diana M., Faure P., Mameli M., Caille S., Georges F.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
13
Numéro
10
Pages
2287-2296
Langue
anglais
Résumé
The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal circuit encoding behavioral effects of cocaine in rats and highlight the importance of adaptive modifications in the BNST, a structure that influences motivated behavior as well as maladaptive behaviors associated with addiction.

Mots-clé
Animals, Cocaine/pharmacology, Cocaine-Related Disorders/physiopathology, Disease Models, Animal, Dopamine Uptake Inhibitors/pharmacology, Dopaminergic Neurons/drug effects, Dopaminergic Neurons/physiology, Electric Stimulation, Hippocampus/drug effects, Hippocampus/physiology, Immunohistochemistry, Motor Activity/drug effects, Motor Activity/physiology, Neural Pathways/drug effects, Neural Pathways/physiology, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Synaptic Transmission/drug effects, Synaptic Transmission/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2017 11:20
Dernière modification de la notice
20/08/2019 14:25
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