Usefulness of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography in patients with neurofibromatosis type 1: a systematic review.

Détails

ID Serval
serval:BIB_6B169F10C480
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Usefulness of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography in patients with neurofibromatosis type 1: a systematic review.
Périodique
Radiology research and practice
Auteur(s)
Treglia G., Taralli S., Bertagna F., Salsano M., Muoio B., Novellis P., Vita M.L., Maggi F., Giordano A.
ISSN
2090-195X (Electronic)
ISSN-L
2090-195X
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
2012
Pages
431029
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Aim. To systematically review the role of positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) in patients with neurofibromatosis type 1 (NF1). Methods. A comprehensive literature search of published studies regarding FDG-PET and PET/CT in patients with NF1 was performed. No beginning date limit and language restriction were used; the search was updated until December 2011. Only those studies or subsets in studies including whole-body FDG-PET or PET/CT scans performed in patients with NF1 were included. Results. We identified 12 studies including 352 NF1 patients. Qualitative evaluation was performed in about half of the studies and semiquantitative analysis, mainly based on different values of SUV cutoff, in the others. Most of the studies evaluated the role of FDG-PET for differentiating benign from malignant peripheral nerve sheath tumors (MPNSTs). Malignant lesions were detected with a sensitivity ranging between 100% and 89%, but with lower specificity, ranging between 100% and 72%. Moreover, FDG-PET seems to be an important imaging modality for predicting the progression to MPNST and the outcome in patients with MPNST. Two studies evaluated the role of FDG-PET in pediatric patients with NF1. Conclusions. FDG-PET and PET/CT are useful methods to identify malignant change in neurogenic tumors in NF1 and to discriminate malignant from benign neurogenic lesions.

Pubmed
Open Access
Oui
Création de la notice
20/08/2017 20:22
Dernière modification de la notice
20/08/2019 14:25
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