Inflammation, immunity and vaccines for Helicobacter pylori

Détails

ID Serval
serval:BIB_6B00177F1431
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Inflammation, immunity and vaccines for Helicobacter pylori
Périodique
Helicobacter
Auteur⸱e⸱s
Del Giudice  G., Michetti  P.
ISSN
1083-4389 (Print)
Statut éditorial
Publié
Date de publication
2004
Volume
9 Suppl 1
Pages
23-8
Notes
Journal Article
Review
Résumé
Helicobacter pylori causes chronic gastritis in the human stomach, yet only a minority of infected individuals develop peptic ulcer disease, atrophic gastritis, or gastric malignancies. The severity, progression, and consequences of H. pylori infection have been shown to depend on the host genetic background, and in particular on gene polymorphisms affecting the host immune response. Numerous studies published last year brought new information on the mechanisms by which the host genetic make-up modifies the inflammatory and immune responses to H. pylori and the induction of tissue damage secondary to the infection. Novel insights on the regulatory role of H. pylori on the adaptive T-cell response and on its consequences for the persistence of the infection and for the development of vaccines are discussed.
Mots-clé
Animals Bacterial Vaccines/*immunology Cytokines/immunology Gastritis/microbiology/pathology Genetic Predisposition to Disease Helicobacter Infections/immunology/*microbiology/prevention & control Helicobacter pylori/*immunology/pathogenicity Humans Immunity/genetics Inflammation/*immunology/pathology Virulence Factors/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 17:02
Dernière modification de la notice
20/08/2019 15:25
Données d'usage